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Randomized Controlled Trial
. 2020 Nov;114(5):1032-1039.
doi: 10.1016/j.fertnstert.2020.06.002. Epub 2020 Oct 6.

Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction

Wendy Vitek  1 , Fangbai Sun  2 , Kathleen M Hoeger  3 , Nanette Santoro  4 , Michael P Diamond  5 , Heping Zhang  2 , Richard S Legro  6 ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network
Collaborators, Affiliations
Randomized Controlled Trial

Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction

Wendy Vitek et al. Fertil Steril. 2020 Nov.

Abstract

Objective: To determine if short-term weight change among women with unexplained infertility (UI) and polycystic ovary syndrome (PCOS) undergoing ovulation induction is associated with live birth.

Design: Secondary analysis of randomized trials.

Setting: Multicenter fertility trial sites.

Patient(s): A total of 900 women with UI and 750 women with PCOS.

Main outcome measure(s): Live birth.

Intervention(s): Weight assessment at enrollment and start of up to 4-5 cycles of clomiphene, letrozole, or gonadotropins and intrauterine insemination for women with UI and clomiphene or letrozole with regular intercourse for women with PCOS.

Result(s): Weight data were available for 856 women with UI and 697 women with PCOS. Mean weight change was -0.2 ± 0.3 kg among women with UI and +2.2 ± 0.2 kg among women with PCOS and did not differ based on treatment allocation. There were 115 women with PCOS (16.4%) who gained ≥3 kg. Increased body mass index and three or more cycles were associated with weight gain in women with PCOS. There was no difference in live birth rate among women with PCOS and ≥3 kg weight gain and women with PCOS who did not gain weight.

Conclusion(s): Women with PCOS gained an average of 2.2 kg regardless of the medication received, whereas women with UI experienced no short-term weight change during ovulation induction. Weight gain in women with PCOS was not associated with live birth rate.

Keywords: Short-term weight change; ovulation induction; polycystic ovary syndrome; unexplained infertility.

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Figures

Figure 1:
Figure 1:. Mean weight (kg) with standard deviations at enrollment and cycle baseline visits by diagnosis/study
Abbreviations: PCOS, polycystic ovary syndrome
See this image and copyright information in PMC

Comment in

  • Infertility: a weight-bearing exercise?
    Boots CE, Swanson AC, Jungheim ES. Boots CE, et al. Fertil Steril. 2020 Nov;114(5):964-965. doi: 10.1016/j.fertnstert.2020.08.006. Epub 2020 Sep 3. Fertil Steril. 2020. PMID: 32892997 No abstract available.

References

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