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Review
. 2020 Nov;46(6):874-893.
doi: 10.1002/biof.1682. Epub 2020 Oct 9.

Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells

Simin Sharifi  1 , Farzin Arablouye Moghaddam  2 , Atefeh Abedi  2 , Solmaz Maleki Dizaj  1 , Shahin Ahmadian  3   4 , Elaheh Dalir Abdolahinia  5 , Seyed Mahdi Hosseiniyan Khatibi  6 , Mohammad Samiei  2   3
Affiliations
Review

Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells

Simin Sharifi et al. Biofactors. 2020 Nov.

Abstract

Medicinal plants have always been utilized for the prevention and treatment of the spread of different diseases all around the world. To name some traditional medicine that has been used over centuries, we can refer to phytochemicals such as naringin, icariin, genistein, and resveratrol gained from plants. Osteogenic differentiation and mineralization of stem cells can be the result of specific bioactive compounds from plants. One of the most appealing choices for therapy can be mesenchymal stem cells (MSCs) because it has a great capability of self-renewal and differentiation into three descendants, namely, endoderm, mesoderm, and ectoderm. Stem cell gives us the glad tidings of great advances in tissue regeneration and transplantation field for treatment of diseases. Using plant bioactive phytochemicals also holds tremendous promises in treating diseases such as osteoporosis. The purpose of the present review article thus is to investigate what are the roles and consequences of phytochemicals on osteogenic differentiation of MSCs.

Keywords: mesenchymal stem cells; osteoblast; osteogenic differentiation; phytochemicals.

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References

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