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. 1987 Jul;115(3):373-7.
doi: 10.1530/acta.0.1150373.

Are Leydig cells of neural origin? Substance P-like immunoreactivity in human testicular tissue

W Schulze, M S Davidoff, A F Holstein

Are Leydig cells of neural origin? Substance P-like immunoreactivity in human testicular tissue

W Schulze et al. Acta Endocrinol (Copenh). 1987 Jul.

Abstract

Using the immunocytochemical peroxidase-antiperoxidase method we observed strong and selective staining of Leydig cells after incubation of human testicular tissue with an antiserum against substance P and a slightly weaker immunoreactivity against methionine-enkephalin. These results indicate that the embryologic origin of Leydig cells may require reconsideration and also offer a new perspective for research upon the local control mechanisms of spermatogenesis.

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