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Case Reports
. 2021 Jan;41(1):251-255.
doi: 10.1007/s10875-020-00889-1. Epub 2020 Oct 10.

A Patient with Novel ICOS Mutation Presented with Progressive Loss of B Cells

Asena Pınar Sefer  1   2   3 , Louis Marie Charbonnier  4 , Nurhan Kasap  1   2   3 , Bengu Akcam  1   2   3 , Yasemin Kendir Demirkol  5 , Sevgi Bilgic Eltan  1   2   3 , Ahmet Ozen  1   2   3 , Elif Karakoc-Aydiner  1   2   3 , Safa Baris  6   7   8
Affiliations
Case Reports

A Patient with Novel ICOS Mutation Presented with Progressive Loss of B Cells

Asena Pınar Sefer et al. J Clin Immunol. 2021 Jan.
No abstract available

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References

    1. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999;397(6716):263–6. - DOI
    1. Schepp J, Chou J, Skrabl-Baumgartner A, Arkwright PD, Engelhardt KR, Hambleton S, et al. 14 years after discovery: clinical follow-up on 15 patients with inducible co-stimulator deficiency. Front Immunol. 2017;8:964. - DOI
    1. Abolhassani H, El-Sherbiny YM, Arumugakani G, Carter C, Richards S, Lawless D, et al. Expanding clinical phenotype and novel insights into the pathogenesis of ICOS deficiency. J Clin Immunol. 2020;40(2):277–88. - DOI
    1. Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, et al. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol. 2009;182(9):5515–27. - DOI
    1. Bousfiha A, Jeddane L, Picard C, Al-Herz W, Ailal F, Chatila T, et al. Human inborn errors of immunity: 2019 update of the IUIS phenotypical classification. J Clin Immunol. 2020;40(1):66–81. - DOI

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