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. 2020 Sep;34(9):805-810.
doi: 10.13201/j.issn.2096-7993.2020.09.009.

[Microbiology of chronic rhinosinusitis with different clinical phenotypes]

[Article in Chinese]
Xiao Liu  1 , Hongbing Liu  1 , Chunhua Li  1 , Wenxia Wu  1
Affiliations

[Microbiology of chronic rhinosinusitis with different clinical phenotypes]

[Article in Chinese]
Xiao Liu et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Sep.

Abstract
in English, Chinese

Objective:To observe the microbiological characteristics and clinical correlation of chronic rhinosinusitis with different clinical phenotypes. Method:One hundred and ninety-six patients with chronic rhinosinusitis（CRS） underwent nasal endoscopic surgery, including 126 patients with Chronic rhinosinusitis with nasal polyps（CRSwNP） and 70 patients with chronic rhinosinusitis without nasal polyps（CRSsNP）; 78 patients with nasal septum deviation（control group） were enrolled. The nasal discharge samples were collected before operation, and the bacteria were isolated and identified by the traditional culture method. The bacteria were compared between the two groups by Pearson chi-square test or Fisher exact test, and the bacteria were compared between groups by Kruskal-Wallis rank sum test. Out statistically significant variables（P<0.05）. Result:The total bacterial detection rate was 73.0% in the three groups, 76.2% in the CRSwNP group, 68.6% in the CRSsNP group and 71.8% in the control group, respectively（P=0.579）. The detection rate of the bacteria was mainly Gram-positive bacteria. The higher detection rate included: Staphylococcus epidermidis, Pseudodiphtheria, Staphylococcus aureus, Haemophilus influenzaemola, Haemella influenzaemola. The detection rate of Haemophilus influenzae in the CRSwNP group and the control group（13.5% vs 2.6%, P=0.009）, but there were statistical differences CRSsNP.There was no statistically significant difference in the detection rate of the bacteria（8.6% vs 2.6%, P=0.15） between the CRSsNP group and the control group; The difference of staphylococcus aureus detection rate between NonECRSwNP group and ECRSwNP group was statistically significant （9.6% vs 28.1%,P=0.017）.There was no significant difference in staphylococcus aureus detection rate between NonECRSsNP group and ECRSsNP group （9.4% vs 16.7%, P=0.482）. Conclusion:Haemophilus influenzae may be a potential cause of CRSwNP; S. aureus may promote the eosinophilic granulocyte inflammatory response to CRSwNP.

目的：观察不同临床表型慢性鼻窦炎（CRS）的微生物学构成特点及临床相关性研究。 方法：收集行鼻内镜手术的CRS患者196例，其中慢性鼻窦炎伴鼻息肉（CRSwNP）患者126例、慢性鼻窦炎不伴鼻息肉（CRSsNP）患者70例，78例鼻中隔偏曲患者（对照组）入组。术前采集中鼻道区域鼻腔分泌物标本，利用传统培养方法进行细菌的分离及鉴定。通过Pearson卡方检验或Fisher精确检验进行两组间细菌的比较，使用Kruskal-Wallis秩和检验对多组间细菌进行比较，筛选有统计学意义的变量。 结果：3组细菌总检出率为73.0%，CRSwNP组、CRSsNP组和对照组细菌检出率分别为76.2%、68.6%、71.8%，3组比较差异无统计学意义（P=0.579）；检出细菌以革兰阳性菌为主；检出率较高的细菌包括表皮葡萄球菌、假白喉棒状杆菌、金黄色葡萄球菌、流感嗜血杆菌、卡他莫拉菌；CRSwNP组与对照组流感嗜血杆菌检出率比较差异有统计学意义（13.5% vs 2.6%，P=0.009），但CRSsNP组和对照组该菌检出率比较差异无统计学意义（8.6% vs 2.6%，P=0.150）；NonECRSwNP组和ECRSwNP组金黄色葡萄球菌检出率比较差异有统计学意义（9.6% vs 28.1%，P=0.017）；NonECRSsNP组和ECRSsNP组金黄色葡萄球菌检出率差异无统计学意义（9.4% vs 16.7%，P=0.482）。 结论：流感嗜血杆菌可能是CRSwNP的潜在病因；金黄色葡萄球菌可以促进CRSwNP嗜酸粒细胞炎症反应。.

Keywords: microbiology; pathogenesis; sinusitis.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

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