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. 2020 Sep;67(2):122-125.
doi: 10.3164/jcbn.20-102. Epub 2020 Aug 21.

Association between selective IgA deficiency and COVID-19

Yuji Naito  1 , Tomohisa Takagi  1 , Tetsuro Yamamoto  2 , Shaw Watanabe  3
Affiliations

Association between selective IgA deficiency and COVID-19

Yuji Naito et al. J Clin Biochem Nutr. 2020 Sep.

Abstract

The purpose of this study was to propose a hypothesis that there is a potential association between the incidence of selective IgA deficiency in various countries and COVID-19 cases. The number of deaths due to COVID-19 increased in clear proportion to the number of infected patients, and the difference in the number of deaths by country was due to the difference in the number of infected patients. The frequency of selective IgA deficiency has a strong positive correlation with the prevalence of COVID-19 per population. The low infection rate contributed to the low death rate from COVID-19 in Japan, suggesting that the extremely low frequency of selective IgA deficiency may be a contributing factor.

Keywords: COVID-19; IgA deficiency; mortality.

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Figures

Fig. 1
Fig. 1
Correlation between the number of patients infected with COVID-19 and the number of deaths.
Fig. 2
Fig. 2
Correlation between the number of patients infected with COVID-19 and the mortality rate.
Fig. 3
Fig. 3
Correlation between the COVID-19 infection rate and frequency of selective IgA deficiency.
See this image and copyright information in PMC

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