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Review
. 2020 Sep 11:11:638.
doi: 10.3389/fendo.2020.00638. eCollection 2020.

Circadian Genes as Therapeutic Targets in Pancreatic Cancer

María García-Costela  1 , Julia Escudero-Feliú  1 , Jose D Puentes-Pardo  1 , Sara Moreno San Juán  2 , Sonia Morales-Santana  3   4 , Sandra Ríos-Arrabal  1 , Ángel Carazo  5 , Josefa León  1   6
Affiliations
Review

Circadian Genes as Therapeutic Targets in Pancreatic Cancer

María García-Costela et al. Front Endocrinol (Lausanne). .

Abstract

Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.

Keywords: chemotherapy; circadian clock; metabolism; pancreatic cancer; precision medicine.

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Figures

Figure 1
Figure 1
Schematic representation of factors driving alterations in the molecular clock that lead to the development of pancreatic cancer and resistance to chemotherapy.
See this image and copyright information in PMC

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