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Review
. 1987;60(1-3):179-81.
doi: 10.1007/BF00296976.

Initiation and promotion in hepatocarcinogenesis

R Schulte-Hermann
Review

Initiation and promotion in hepatocarcinogenesis

R Schulte-Hermann. Arch Toxicol. 1987.

Abstract

Initiation and promotion have been recognized as essential parts of the multi-stage concept of chemical carcinogenesis. In the liver, initiation by genotoxic carcinogens results in appearance of foci of phenotypically altered hepatocytes. Accelerated growth and phenotypic changes of these foci during tumor promotion by phenobarbital are described, and possible mechanisms of initiation and promotion considered.

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References

    1. CRC Crit Rev Toxicol. 1974 Jan;2(4):419-43 - PubMed
    1. Carcinogenesis. 1986 Aug;7(8):1351-7 - PubMed
    1. Nature. 1985 May 30-Jun 5;315(6018):382-5 - PubMed
    1. Carcinogenesis. 1984 Jan;5(1):41-6 - PubMed
    1. Naturwissenschaften. 1978 Dec;65(12):640-8 - PubMed

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