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. 2020 Sep 21;12(Suppl 1):8954.
doi: 10.4081/hr.2020.8954.

How I manage frontline transplant-eligible multiple myeloma in Italy

Vittorio Montefusco  1 , Giovanni Martinelli  2 , Claudio Cerchione  2
Affiliations

How I manage frontline transplant-eligible multiple myeloma in Italy

Vittorio Montefusco et al. Hematol Rep. .

Abstract

The treatment of transplant-eligible multiple myeloma patients in Italy consists in an induction phase based on bortezomib plus thalidomide plus dexamethasone (VTd), followed by a single or tandem autologous stem cell transplantation (ASCT), followed by lenalidomide maintenance. This approach offers an overall response rate of 93% and a CR rate of 58% with acceptable toxicity. Lenalidomide maintenance adds a significant increase in disease control, with a progression free survival after ASCT of 53 months, and an overall survival of 86 months. Second primary malignancies represent the most concerning toxicity of lenalidomide maintenance with a 6.9% incidence. However, the benefit in terms of increased myeloma control largely outweigh this complication. The incorporation of daratumumab in this treatment schema will further improve these clinical results.

Keywords: Multiple myeloma; autologous stem cell transplantation; bortezomib; lenalidomide.

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Conflict of interest statement

Conflict of interest: VM has received honoraria and travel grants from Janssen, Celgene, Bristol-Myers Squibb, Amgen and Takeda.

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