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Review
. 2020 Sep 1;10(9):2705-2729.
eCollection 2020.

The role of Aurora-A in human cancers and future therapeutics

Xinrong Lin  1 , Xiaosong Xiang  2 , Liping Hao  1 , Ting Wang  1 , Yongting Lai  3 , Mubalake Abudoureyimu  1 , Hao Zhou  1 , Bing Feng  1 , Xiaoyuan Chu  1 , Rui Wang  1
Affiliations
Review

The role of Aurora-A in human cancers and future therapeutics

Xinrong Lin et al. Am J Cancer Res. .

Abstract

Aurora-A is a mitotic serine/threonine-protein kinase and an oncogene. In normal cells, Aurora-A appears from G2 phase and localizes at the centrosome, where it participates in centrosome replication, isolation and maturation. Aurora-A also maintains Golgi apparatus structure and spindle assembly. Aurora-A undergoes ubiquitination-mediated degradation after the cell division phase. Aurora-A is abnormally expressed in tumor cells and promotes cell proliferation by regulating mitotic substrates, such as PP1, PLK1, TPX2, and LAST2, and affects other molecules through a non-mitotic pathway to promote cell invasion and metastasis. Some molecules in tumor cells also indirectly act on Aurora-A to regulate tumor cells. Aurora-A also mediates resistance to chemotherapy and radiotherapy and is involved in tumor immunotherapy. Clinical trials of Aurora-A molecular inhibitors are currently underway, and clinical transformation is just around the corner.

Keywords: Aurora-A; cancer; clinical.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Aurora-A structure diagram.
Figure 2
Figure 2
Schematic diagram of changes in centromere and Aurora-A during the cell cycle. The background color in the figure represents the expression level of Aurora-A.
Figure 3
Figure 3
Regulation of tumorigenesis and development.
Figure 4
Figure 4
Mechanism of Aurora-A mediated chemotherapy and radiotherapy.
Figure 5
Figure 5
The chemical structure of Aurora kinase inhibitors. (From PubChem: https://pubchem.ncbi.nlm.nih.gov/). A. Structure of PHA-79358. B. Structure of MK-0457. C. Structure of MSC1992371A. D. Structure of ABT-348. E. Structure of BI-847325. F. Structure of ENMD-2076. G. Structure of AT9283. H. Structure of AMG900. I. Structure of PF-03814735. J. Structure of MLN8237. K. Structure of MLN8054. L. Structure of MK-5108. M. Structure of AZD-1152. N. Structure of BI-831266.
See this image and copyright information in PMC

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