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Review
. 2020 Sep 11:10:538845.
doi: 10.3389/fonc.2020.538845. eCollection 2020.

Molecular Mechanism and Approach in Progression of Meningioma

Zhiwei Shao  1 , Lihong Liu  2 , Yanghao Zheng  3 , Sheng Tu  3 , Yuanbo Pan  4 , Sheng Yan  1 , Qichun Wei  2 , Anwen Shao  4 , Jianmin Zhang  4   5   6
Affiliations
Review

Molecular Mechanism and Approach in Progression of Meningioma

Zhiwei Shao et al. Front Oncol. .

Erratum in

Abstract

Meningioma is the most common tumor of the central nervous system, most of which is benign. Even after complete resection, a high rate of recurrence of meningioma is observed. From in-depth study of its pathogenesis, it has been found that a number of chromosomal variations and abnormal molecular signals are closely related to the occurrence and development of malignancy in meningioma, which may provide the theoretical basis and potential direction for accurate and targeted treatment. We have reviewed advances in chromosomal variations and molecular mechanisms involved in the progression of meningioma, and have highlighted the association with malignant biological behavior including cell proliferation, angiogenesis, increased invasiveness, and inhibition of apoptosis. In addition, the chemotherapy of meningioma is summarized and discussed.

Keywords: angiogenesis; apoptosis; chromosomal abnormality; genetics; invasiveness; mechanism; meningioma.

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Figures

FIGURE 1
FIGURE 1
Chromosomal abnormalities in the progression of meningioma.
FIGURE 2
FIGURE 2
PI3K/Akt pathway is involved in cell growth, differentiation, and tumorigenesis. When the ligand binds to the membrane receptor, the receptor activates PI3K, which then catalyzes the formation of PI3P from PIP2 on the inner surface of the membrane. As the second messenger, PI3P further activated Akt. Akt can activate the downstream mTOR pathway, which can phosphorylate and activate S6K1 and 4EBP, and finally participate in gene expression.
FIGURE 3
FIGURE 3
The mechanism of increased invasiveness in meningioma.
FIGURE 4
FIGURE 4
The mechanism of angiogenesis in meningioma.
FIGURE 5
FIGURE 5
Molecular mechanism of Wnt/β-catenin signaling pathway activation.
See this image and copyright information in PMC

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