Fading of Deep Brain Stimulation Efficacy Versus Disease Progression: Untangling a Gordian Knot

Alfonso Fasano^{1

2

3

4}, Marcelo Merello^{5

6

7}

Affiliations

¹ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital, UHN Toronto Ontario Canada.
² Division of Neurology University of Toronto Toronto Ontario Canada.
³ Krembil Brain Institute Toronto Ontario Canada.
⁴ Center for Advancing Neurotechnological Innovation to Application Toronto Ontario Canada.
⁵ Edmond J. Safra Program in Parkinson's Disease, Movement Disorders Unit, Neuroscience Department Raul Carrea Institute of Neurological Research, FLENI Buenos Aires Argentina.
⁶ Pontifical Catholic University of Argentina Buenos Aires Argentina.
⁷ National Scientific and Technological Research Council Buenos Aires Argentina.

PMID: 33043072
PMCID: PMC7533966
DOI: 10.1002/mdc3.13041

Editorial

Fading of Deep Brain Stimulation Efficacy Versus Disease Progression: Untangling a Gordian Knot

Alfonso Fasano et al. Mov Disord Clin Pract. 2020.

. 2020 Sep 21;7(7):747-749.

doi: 10.1002/mdc3.13041. eCollection 2020 Oct.

Authors

Alfonso Fasano^{1

2

3

4}, Marcelo Merello^{5

6

7}

Affiliations

¹ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital, UHN Toronto Ontario Canada.
² Division of Neurology University of Toronto Toronto Ontario Canada.
³ Krembil Brain Institute Toronto Ontario Canada.
⁴ Center for Advancing Neurotechnological Innovation to Application Toronto Ontario Canada.
⁵ Edmond J. Safra Program in Parkinson's Disease, Movement Disorders Unit, Neuroscience Department Raul Carrea Institute of Neurological Research, FLENI Buenos Aires Argentina.
⁶ Pontifical Catholic University of Argentina Buenos Aires Argentina.
⁷ National Scientific and Technological Research Council Buenos Aires Argentina.

PMID: 33043072
PMCID: PMC7533966
DOI: 10.1002/mdc3.13041

No abstract available

PubMed Disclaimer

Conflict of interest statement

This work did not receive funding. A.F. received honoraria and/or research support from Abbott, Boston Scientific, Brainlab, Ceregate, and Medtronic. M.M. received honoraria and/or research support from Abbott.

Figures

**FIG. 1**
A possible framework to understand the natural history of PD after STN DBS. Besides the obvious selection bias at the time of surgery (eg, patients with good cognition, no comorbidities, and so on are offered DBS), other long‐term effects are indirectly or directly related to DBS. Tremor reduction is the only proven direct effect of DBS on disease progression so far. DBS, deep brain stimulation; PD, Parkinson's disease; STN, subthalamic nucleus.

See this image and copyright information in PMC

Cited by

Predicting Motor Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Using Quantitative Susceptibility Mapping and Radiomics: A Pilot Study.
Liu Y, Xiao B, Zhang C, Li J, Lai Y, Shi F, Shen D, Wang L, Sun B, Li Y, Jin Z, Wei H, Haacke EM, Zhou H, Wang Q, Li D, He N, Yan F. Liu Y, et al. Front Neurosci. 2021 Sep 7;15:731109. doi: 10.3389/fnins.2021.731109. eCollection 2021. Front Neurosci. 2021. PMID: 34557069 Free PMC article.
Morbidity Milestones Demonstrate Long Disability-Free Survival in Parkinson's Disease Patients with Deep Brain Stimulation of the Subthalamic Nucleus.
Schnalke N, Konitsioti A, Frank A, Kurz M, Polanski WH, Themann P, Wolz M, Sobottka SB, Reichmann H, Falkenburger B, Klingelhoefer L. Schnalke N, et al. Mov Disord Clin Pract. 2023 Feb 28;10(4):569-578. doi: 10.1002/mdc3.13698. eCollection 2023 Apr. Mov Disord Clin Pract. 2023. PMID: 37070057 Free PMC article.
Deep Brain Stimulation Selection Criteria for Parkinson's Disease: Time to Go beyond CAPSIT-PD.
Artusi CA, Lopiano L, Morgante F. Artusi CA, et al. J Clin Med. 2020 Dec 4;9(12):3931. doi: 10.3390/jcm9123931. J Clin Med. 2020. PMID: 33291579 Free PMC article. Review.

References

1. Krack P, Batir A, Van Blercom N, et al. Five‐year follow‐up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 2003;349:1925–1934. - PubMed
1. Fasano A, Romito LM, Daniele A, et al. Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants. Brain 2010;133:2664–2676. - PubMed
1. Rizzone MG, Fasano A, Daniele A, et al. Long‐term outcome of subthalamic nucleus DBS in Parkinson's disease: from the advanced phase towards the late stage of the disease? Parkinsonism Relat Disord 2014;20:376–381. - PubMed
1. Fasano A, Aquino CC, Krauss JK, Honey CR, Bloem BR. Axial disability and deep brain stimulation in patients with Parkinson disease. Nat Rev Neurol 2015;11:98–110. - PubMed
1. Constantinescu R, Eriksson B, Jansson Y, et al. Key clinical milestones 15 years and onwards after DBS‐STN surgery‐a retrospective analysis of patients that underwent surgery between 1993 and 2001. Clin Neurol Neurosurg 2017;154:43–48. - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Fading of Deep Brain Stimulation Efficacy Versus Disease Progression: Untangling a Gordian Knot

Affiliations

Fading of Deep Brain Stimulation Efficacy Versus Disease Progression: Untangling a Gordian Knot

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources