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. 2021 Feb;35(2):e23613.
doi: 10.1002/jcla.23613. Epub 2020 Oct 11.

Assessment of serum phenylalanine and tyrosine isomers in patients with ST-segment elevation vs non-ST-segment elevation myocardial infarction

Ied Al-Sadoon  1 , István Wittmann  2 , Szilard Kun  2 , Mercédesz Ahmann  1 , Attila Konyi  3 , Zsófia Verzár  1
Affiliations

Assessment of serum phenylalanine and tyrosine isomers in patients with ST-segment elevation vs non-ST-segment elevation myocardial infarction

Ied Al-Sadoon et al. J Clin Lab Anal. 2021 Feb.

Abstract

Background: Under conditions of oxidative stress, hydroxyl radicals can oxidize phenylalanine (Phe) into various tyrosine (Tyr) isomers (meta-, ortho-, and para-tyrosine; m-, o-, and p-Tyr), depending on the location of the hydroxyl group on the oxidized benzyl ring. This study aimed to compare patients with ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) and the serum levels of Phe and Tyr isomers at the aortic root and distal to the culprit lesion in both groups.

Methods: Forty-four patients participated in the study: 23 with STEMI and 21 with NSTEMI. Arterial blood samples were taken from the aortic root through a guiding catheter and from the culprit vessel segment distal from the primary lesion with an aspiration catheter, during the percutaneous coronary intervention. Serum levels of Phe, p-Tyr, m-Tyr, and o-Tyr were determined using reverse-phase high-performance liquid chromatography.

Results: Serum levels of Phe were significantly higher distal to the culprit lesion compared to the aortic root in patients with STEMI. Serum p-Tyr/Phe and m-Tyr/Phe concentration ratios were both lower distal to the culprit lesion than at the aortic root in patients with STEMI. There were no statistically significant differences with respect to changes in serum Phe and Tyr isomers distal to the culprit lesion compared to the aortic root in patients with NSTEMI.

Conclusion: Our data suggest that changes in serum levels of different Tyr isomers can mediate the effects of oxidative stress during myocardial infarction.

Keywords: meta-tyrosine; myocardial infarction; ortho-tyrosine; oxidative stress; para-tyrosine; phenylalanine.

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Figures

FIGURE 1
FIGURE 1
Oxidation of phenylalanine into different tyrosine isoforms due to the activity of the phenylalanine hydroxylase enzyme or under conditions of oxidative stress (mainly via hydroxyl free radicals)
FIGURE 2
FIGURE 2
Scatter plot of serum m‐Tyr levels at the aortic root vs the extent of CAD (represented as number of diseased vessels) in patients with (A) STEMI and (B) NSTEMI
See this image and copyright information in PMC

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