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. 2020 Oct;48(10):300060520961260.
doi: 10.1177/0300060520961260.

Risk factors for early postoperative recurrence in single and small hepatitis B virus-associated primary hepatocellular carcinoma

Hongmei Jin  1 , Hui Wang  1 , Guanghao Li  2 , Qingshun Hou  1 , Wei Wu  1 , Fuhui Liu  1
Affiliations

Risk factors for early postoperative recurrence in single and small hepatitis B virus-associated primary hepatocellular carcinoma

Hongmei Jin et al. J Int Med Res. 2020 Oct.

Abstract

Objective: To investigate the risk factors of early postoperative recurrence in patients with single and small (≤3 cm) hepatitis B virus-associated primary hepatocellular carcinoma (HBV-HCC).

Methods: This retrospective study analyzed patients with single and small HBV-HCC. All patients were followed up for 1 year after surgery.

Results: Among 182 patients, 54 patients had early recurrence within 1 year. The recurrence group had higher proportions of men, drinking history, Child-Turcotte-Pugh (CTP) class C, patients who underwent transarterial chemoembolization (TACE), and serum alpha-fetoprotein (AFP) >10 ng/mL as well as higher gamma-glutamyl transpeptidase (GGT) levels and lower total protein (TP) and CD8+ T lymphocyte levels than the no recurrence group. Cox multivariate regression analysis demonstrated that drinking history (HR, 1.312; 95% CI, 1.042-1.652), CTP class C (HR, 1.236; 95% CI, 1.037-1.473), TACE treatment (HR, 1.241; 95% CI, 1.026-1.501), GGT (HR, 1.138; 95% CI, 1.042-1.243), TP (HR, 0.729; 95% CI, 0.555-0.957), and AFP (HR, 2.519; 95% CI, 1.343-4.726) were independently associated with early postoperative recurrence.

Conclusion: Drinking history, CTP class C, TACE, serum AFP, GGT, and TP levels were independently associated with early postoperative recurrence in patients with single and small HBV-HCC.

Keywords: Child–Turcotte–Pugh; Hepatitis B virus; alpha-fetoprotein; drinking history; gamma-glutamyl transpeptidase; primary hepatocellular carcinoma; prognosis; recurrence; total protein; transarterial chemoembolization.

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Figures

Figure 1.
Figure 1.
Flowchart of this study.
Figure 2.
Figure 2.
Drinking history, CTP class, AFP levels, and treatment methods were associated with early recurrence of single and small HBV-HCC. The Kaplan–Meier method was used to draw the cumulative recurrence free survival and the differences were compared between groups using the log-rank test. (a) Drinking history, (b) CTP class, (c) AFP level, and (d) Treatment method. CTP, Child–Turcotte–Pugh grade; AFP, α-fetoprotein; HBV, hepatitis B virus; HCC, hepatocellular carcinoma.
See this image and copyright information in PMC

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