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Review
. 2020 Dec;33(6):530-539.
doi: 10.1097/QCO.0000000000000688.

Clinical application of non-coding RNAs in sepsis

Mildred A Iro  1   2 , Sudha Priya Soundara Pandi  1
Affiliations
Review

Clinical application of non-coding RNAs in sepsis

Mildred A Iro et al. Curr Opin Infect Dis. 2020 Dec.

Abstract

Purpose of review: Studies indicating that non-coding RNAs (ncRNAs) play a regulatory role in sepsis are increasing rapidly. This present review summarizes recent publications on the role of microRNAs and long non-coding RNAs (lncRNAs) in sepsis.

Recent findings: MicroRNAs (miRNAs) and lncRNAs are being identified as potential sepsis biomarkers and therapeutic targets. Experimental studies have examined the biological mechanisms that might underpin the regulatory role of these ncRNAs in sepsis.

Summary: Clinical applications of miRNAs and lncRNAs in sepsis are on the horizon. These data could lead to the identification of novel treatments or indeed support the repurposing of existing drugs for sepsis. Validation of the findings from these preliminary studies and crucially integration of multiomics datasets will undoubtedly revolutionize the clinical management of sepsis.

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References

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