Restrictive Versus Liberal Transfusion Trials: Are They Asking the Right Question?

Kevin M Trentino^{1

2}, Shannon L Farmer^{3

4}, James P Isbister⁵, Frank M Sanfilippo¹, Michael F Leahy^{6

7}, Axel Hofmann^{3

8}, Aryeh Shander⁹, Kevin Murray¹

Affiliations

¹ From the School of Population and Global Health, The University of Western Australia, Perth, Australia.
² Data and Digital Innovation, East Metropolitan Health Service, Perth, Australia.
³ Medical School and Division of Surgery, The University of Western Australia, Perth, Australia.
⁴ Department of Haematology, Royal Perth Hospital, Perth, Australia.
⁵ School of Medicine, The University of Sydney, Sydney, Australia.
⁶ Department of Haematology, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia.
⁷ School of Medicine and Laboratory Science, The University of Western Australia, Perth, Australia.
⁸ Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland.
⁹ Department of Anesthesiology, Englewood Hospital and Medical Center, TeamHealth Research Institute, Englewood, New Jersey.

Comparative Study

Kevin M Trentino et al. Anesth Analg. 2020 Dec.

. 2020 Dec;131(6):1950-1955.

doi: 10.1213/ANE.0000000000005227.

Kevin M Trentino^{1

2}, Shannon L Farmer^{3

4}, James P Isbister⁵, Frank M Sanfilippo¹, Michael F Leahy^{6

7}, Axel Hofmann^{3

8}, Aryeh Shander⁹, Kevin Murray¹

¹ From the School of Population and Global Health, The University of Western Australia, Perth, Australia.
² Data and Digital Innovation, East Metropolitan Health Service, Perth, Australia.
³ Medical School and Division of Surgery, The University of Western Australia, Perth, Australia.
⁴ Department of Haematology, Royal Perth Hospital, Perth, Australia.
⁵ School of Medicine, The University of Sydney, Sydney, Australia.
⁶ Department of Haematology, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia.
⁷ School of Medicine and Laboratory Science, The University of Western Australia, Perth, Australia.
⁸ Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland.
⁹ Department of Anesthesiology, Englewood Hospital and Medical Center, TeamHealth Research Institute, Englewood, New Jersey.

No abstract available

References

1. Trentino KM, Farmer SL, Leahy MF, et al. Systematic reviews and meta-analyses comparing mortality in restrictive and liberal haemoglobin thresholds for red cell transfusion: an overview of systematic reviews. BMC Med. 2020;18:154.
1. Trentino K, Farmer S, Gross I, Shander A, Isbister J. Observational studies - should we simply ignore them in assessing transfusion outcomes? BMC Anesthesiol. 2016;16:96.
1. Mazer CD, Whitlock RP, Fergusson DA, et al.; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group. Restrictive or liberal red-cell transfusion for cardiac surgery. N Engl J Med. 2017;377:2133–2144.
1. Grover M, Talwalkar S, Casbard A, et al. Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. Vox Sang. 2006;90:105–112.
1. So-Osman C, Nelissen R, Te Slaa R, Coene L, Brand R, Brand A. A randomized comparison of transfusion triggers in elective orthopaedic surgery using leucocyte-depleted red blood cells. Vox Sang. 2010;98:56–64.