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. 2021 Mar;38(2):116-120.
doi: 10.4274/balkanmedj.galenos.2020.2020.5.70.

The evaluation of vitamin K status in children with febrile seizure

Kürşat Bora Carman  1 , Yasemin Karal  2 , Gül Gülen Mert  3 , Arzu Ekici  4 , Peren Perk  5 , Coşkun Yarar  1 , Çağatay Nuhoğlu  6 , Gürkan Bozan  7 , Ömer Kılıç  7 , Meltem Dinleyici  7 , Sabiha Şahin  7 , Emrah Atay  8 , Uğur Tokdemir  7 , Baver Demir  5 , Ener Çağrı Dinleyici  7 , Dinleyici Ec Efes Study Group  9
Affiliations

The evaluation of vitamin K status in children with febrile seizure

Kürşat Bora Carman et al. Balkan Med J. 2021 Mar.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Balkan Med J. 2022 Jan 25;39(1):80. doi: 10.4274/balkanmedj.galenos.2021.30112021. Balkan Med J. 2022. PMID: 35330550 Free PMC article. No abstract available.

Abstract

Background: Febrile seizure is the most common neurological disorder in childhood. The exact pathophysiology of febrile seizures is unknown. Recent studies showed the role of vitamin K in nonhematological and inflammatory disorders. This study aimed to investigate the serum vitamin K levels in children with febrile seizures.

Aims: To evaluate vitamin K levels in children with febrile seizures.

Study design: Prospective case-control study.

Methods: This multicenter study examined representative populations in 8 different cities in Turkey between April 1, 2018 and April 1, 2019. Blood samples were taken from all children at presentation. Vitamin K1, vitamin K2, tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels were determined by enzyme-linked immunosorbent assay.

Results: A total of 155 children were included in the study-84 children with febrile seizures and 71 children in febrile control group. Serum vitamin K1 and vitamin K2 levels were also higher in children with febrile seizures than in the controls. The results of statistical analysis showed that vitamin K1 and vitamin K2 levels were correlated with tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels. The median vitamin K1 and vitamin K2 levels of children experiencing their first febrile seizure were higher than those in children with recurrent febrile seizures. Type of febrile seizure has no effect on serum vitamin K1 and vitamin K2 levels.

Conclusion: In children with febrile seizures, vitamin K levels are higher than those in the control group. These new findings may contribute to elucidating the etiopathogenesis of febrile seizures.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

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