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Randomized Controlled Trial
. 2020 Nov;146(5):e20200669.
doi: 10.1542/peds.2020-0669. Epub 2020 Oct 12.

Web-Based Tailored Messaging to Increase Vaccination: A Randomized Clinical Trial

Jason M Glanz  1   2 , Nicole M Wagner  3   4 , Komal J Narwaney  3 , Jennifer Pyrzanowski  4 , Bethany M Kwan  4   5 , Carter Sevick  4 , Kenneth Resnicow  6 , Amanda F Dempsey  4   7
Affiliations
Randomized Controlled Trial

Web-Based Tailored Messaging to Increase Vaccination: A Randomized Clinical Trial

Jason M Glanz et al. Pediatrics. 2020 Nov.

Abstract

Background: To increase vaccine acceptance, we created a Web-based the "Vaccines and Your Baby" intervention (VAYB) that provided new parents with vaccine information messages tailored to vaccine beliefs and values. We evaluated the effectiveness of the VAYB by comparing timely uptake of infant vaccines to an untailored version of the intervention (UT) or usual care intervention (UC) only.

Methods: Between April 2016 and June 2019, we conducted a randomized clinical trial. Pregnant women and new parents were randomly assigned to the VAYB, UT, or UC arms. In the VAYB and UT arms, participants were exposed to interventions at 4 time points from pregnancy until their child was 15 months of age. The primary outcome was up-to-date status for recommended vaccines from birth to 200 days of age. A modified intent-to-treat analysis was conducted. Data were analyzed with logistic regression to generate odds ratios (ORs) and 95% confidence intervals (CIs).

Results: We enrolled 824 participants (276 VAYB, 274 UT, 274 UC), 143 (17.4%) of whom were lost to follow-up. The up-to-date rates in the VAYB, UT, and UC arms were 91.44%, 92.86%, and 92.31%, respectively. Infants in the VAYB arm were not more likely to be up to date than infants in the UC arm (OR = 0.89; 95% CI, 0.45-1.76) or in the UT arm (OR = 0.82; 95% CI, 0.42-1.63). The odds of being up to date did not differ between UT and UC arms (OR = 1.08; 95% CI, 0.54-2.18).

Conclusions: Delivering Web-based vaccine messages tailored to parents' vaccine attitudes and values did not positively impact the timely uptake of infant vaccines.

Trial registration: ClinicalTrials.gov NCT02665013.

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Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Consolidated Standards of Reporting Trials (CONSORT) study flow diagram.
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Comment in

References

    1. Centers for Disease Control and Prevention Ten great public health achievements--United States, 2001–2010. MMWR Morbidity and Mortality Weekly Report. 2011;60(19):619–623 - PubMed
    1. Glanz JM, Newcomer SR, Narwaney KJ, et al. . A population-based cohort study of undervaccination in 8 managed care organizations across the United States. JAMA Pediatr. 2013;167(3):274–281 - PubMed
    1. Dempsey AF, Schaffer S, Singer D, Butchart A, Davis M, Freed GL. Alternative vaccination schedule preferences among parents of young children. Pediatrics. 2011;128(5):848–856 - PubMed
    1. Kempe A, Saville AW, Albertin C, et al. . Parental hesitancy about routine childhood and influenza vaccinations: a national survey. Pediatrics. 2020;146(1):e20193852. - PMC - PubMed
    1. Phadke VK, Bednarczyk RA, Salmon DA, Omer SB. Association between vaccine refusal and vaccine-preventable diseases in the United States: a review of measles and pertussis. JAMA. 2016;315(11):1149–1158 - PMC - PubMed

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