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Meta-Analysis
. 2020 Nov 24;100(18):adv00330.
doi: 10.2340/00015555-3660.

Prevalence and Odds of Signs of Depression and Anxiety in Patients with Lichen Planus: Systematic Review and Meta-analyses

Isabelle Jalenques  1 , Sophie Lauron, Sebastien Almon, Bruno Pereira, Michel D'Incan, Fabien Rondepierre
Affiliations
Meta-Analysis

Prevalence and Odds of Signs of Depression and Anxiety in Patients with Lichen Planus: Systematic Review and Meta-analyses

Isabelle Jalenques et al. Acta Derm Venereol. .

Abstract

The association between certain chronic inflammatory skin diseases and psychiatric disorders or conditions has been well documented. However, the exact magnitude of the association between lichen planus and depression/anxiety symptoms and disorders is un-known. A systematic review and pooled meta-analyses were performed to examine the prevalence and odds of depression and anxiety in patients with lichen planus. The meta-analyses showed a high prevalence of signs of depression (27% [19-36%]) and anxiety (28% [21-36%]). The geographical location of the study may partly explain these vari-ations, but method-ological differences could also be involved. Case-control studies showed a strong association between lichen planus and signs of depression (odds ratio 3.79, 95% confidence interval [2.35; 6.12]) or anxiety (odds ratio 2.54, 95% confidence interval [1.73; 3.72]). These results raise the necessity of screening for the presence of depressive and anxiety symptoms or disorders in patients with lichen planus, and of referring such patients for psychiatric evaluation and appropriate treatment, if necessary.

Keywords: anxiety; depression; lichen planus; meta-analysis.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Flow diagram of article selection for the meta-analysis of the prevalence of depression and anxiety in lichen planus (LP) (Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PRISMA 2009). The numbers (n) on the left represent the number of articles on depression and those on the right the number of articles on anxiety (Depression/Anxiety).
Fig. 2
Fig. 2
Meta-analysis of the prevalence of signs of depression in lichen planus. CI: confidence interval; ES: Effect Size (prevalence).
Fig. 3
Fig. 3
Odds ratio (OR) meta-analysis of the association between signs of depression and lichen planus. CI: confidence interval.
Fig. 4
Fig. 4
Meta-analysis of the prevalence of signs of anxiety in lichen planus. CI: confidence interval. ES: Effect Size (prevalence).
Fig. 5
Fig. 5
Odds ratio(OR) meta-analysis of the association between signs of anxiety and lichen planus. CI: confidence interval.
See this image and copyright information in PMC

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