Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct;159(2):330-342.
doi: 10.1111/jnc.15216. Epub 2020 Nov 1.

Spatially resolved mass spectrometry analysis of amyloid plaque-associated lipids

Martina Blank  1   2 , Carsten Hopf  1
Affiliations
Review

Spatially resolved mass spectrometry analysis of amyloid plaque-associated lipids

Martina Blank et al. J Neurochem. 2021 Oct.

Abstract

Over the last 10 years, considerable technical advances in mass spectrometry (MS)-based bioanalysis have enabled the investigation of lipid signatures in neuropathological structures. In Alzheimer´s Disease (AD) research, it is now well accepted that lipid dysregulation plays a key role in AD pathogenesis and progression. This review summarizes current MS-based strategies, notably MALDI and ToF-SIMS imaging as well as laser capture microdissection combined with LC-ESI-MS. It also presents recent advances to assess lipid alterations associated with Amyloid-β plaques, one of the hallmarks of AD. Collectively, these methodologies offer new opportunities for the study of lipids, thus pushing forward our understanding of their role in such a complex and still untreatable disease as AD.

Keywords: Alzheimer´s disease; Amyloid-β plaques; mass spectrometry; mass spectrometry imaging; plaque-associated lipids; plaque-associated microglia.

PubMed Disclaimer

References

REFERENCES

    1. Aikawa, T., Holm, M.-L., & Kanekiyo, T. (2018). ABCA7 and pathogenic pathways of Alzheimer’s disease. Brain Sciences, 8, 27.
    1. Alzheimer, A. (1907). Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift Fur Psychiatrie Und Psychisch-gerichtliche Medizin, 64, 146-148.
    1. Angel, P. M., & Caprioli, R. M. (2013). Matrix-assisted laser desorption ionization imaging mass spectrometry: In situ molecular mapping. Biochemistry, 52, 3818-3828. https://doi.org/10.1021/bi301519p
    1. Ariga, T., McDonald, M. P., & Yu, R. K. (2008). Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease-a review. Journal of Lipid Research, 49, 1157-1175.
    1. Astarita, G., Jung, K.-M., Vasilevko, V., Dipatrizio, N. V., Martin, S. K., Cribbs, D. H., Head, E., Cotman, C. W., & Piomelli, D. (2011). Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One, 6, e24777. https://doi.org/10.1371/journal.pone.0024777

Publication types

MeSH terms

LinkOut - more resources