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. 2021 Apr;21(4):1667-1669.
doi: 10.1111/ajt.16353. Epub 2020 Oct 31.

SARS-CoV-2 viral dynamics in immunocompromised patients

Sophie Caillard  1   2 , Ilies Benotmane  1   2   3 , Gabriela Gautier Vargas  1 , Peggy Perrin  1   2 , Samira Fafi-Kremer  2   3
Affiliations

SARS-CoV-2 viral dynamics in immunocompromised patients

Sophie Caillard et al. Am J Transplant. 2021 Apr.
No abstract available

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Figures

FIGURE 1
FIGURE 1
(A) Temporal profile of viral loads in nasopharyngeal swab, saliva, and respiratory specimens obtained from kidney transplant recipients according to the days from the onset of symptoms. Each line represents a patient, whereas one case denotes 1 day (days from the onset of symptoms). The first colored box is the day of the diagnosis. The numbers express viral loads (log10 copies/reaction). To convert viral loads from copies/reaction to copies/mL, add 1.69 log. The gray cases indicate the days either before COVID-19 diagnosis or following patient death. Red cases denote the days until the viral load was measured below 3 log10 copies/reaction, whereas orange cases indicate the days until the viral load became undetectable. Green cases denote days from which viral loads were undetectable until day 60. Patient death; *viral loads measured in tracheal aspiration fluid or BAL; **viral loads measured in saliva (while negative in the nasopharyngeal swab). (B) General dynamics of viral loads reduction in nasopharyngeal swabs from 42 kidney transplant recipients with COVID-19. Days from the onset of symptoms are plotted along the X axis, whereas viral loads (log10 copies/ reaction) are represented along the Y axis. To convert viral loads from copies/reaction to copies/mL, add 1.69 log. Viral loads were high (3.9 log copies/mL) between 0 and 15 days from the onset of symptoms (plain square), intermediate (1.6 log copies/ reaction) between 15 and 30 days (dashed square), and low (<3 log copies/reaction) between 30 and 60 days (dotted square). Thirty-five percent of specimens were tested positive between day 30 and day 60 and 5 patients had still viral load above 3 log copies/reaction after day 30 (circles). The minimum detection limit of the RT-PCR assay for the identification of SARS-CoV-2 was 10 copies/reaction [Color figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

References

    1. Zheng S, Fan J, Yu F, et al. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. BMJ. 2020:m1443. - PMC - PubMed
    1. Protocol: real-time RT-PCR assays for the detection of SARS-CoV-2 Institut Pasteur, Paris. https://www.who.int/docs/default-source/coronaviruse/real-time-rt-pcr-as.... Accessed June 1, 2020.
    1. Arons MM, Hatfield KM, Reddy SC, et al. Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. N Engl J Med. 2020;382(22):2081–2090. doi: 10.1056/NEJMoa2008457. - DOI - PMC - PubMed
    1. To K-W, Tsang O-Y, Leung W-S, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020;20:565–574. - PMC - PubMed
    1. Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581(7809):465–469. - PubMed