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. 2020;80(5):505-511.

[Coagulopathy and COVID-19. Recommendations for a changing reality]

[Article in Spanish]
Dardo Riveros  1 , Daniela Maymó  2 , Julia Laviano  2 , Florencia Fornillo Fornillo  2 , José Fernández  2 , Ricardo Benzadon  2 , Jorge Solimano  2 , Roberto Cacchione  2 , Leandro Riera  2 , Patricio Duarte  2 , Nicolás Cazap  2 , Daniel Gotta  2 , Juan García Altuve  2 , Ricardo Valentini  3 , Juan Dupont  2
Affiliations
  • PMID: 33048795
Free article

[Coagulopathy and COVID-19. Recommendations for a changing reality]

[Article in Spanish]
Dardo Riveros et al. Medicina (B Aires). 2020.
Free article

Abstract
in English, Spanish

The coronavirus disease 2019 (COVID-19) pandemic requires rapid medical responses. The risk of venous and arterial thromboembolism increases in critically ill patients with SARS-CoV-2 infection. There is a hypercoagulable state that includes elevated levels of D-dimer, with an increased risk of organ failure and increased mortality. The abnormalities described in hemostasis should be considered for therapeutic decision making. We analyzed the available scientific evidence for the therapeutic approach of coagulopathy in the course of the disease with the objective of designing realistic therapeutic recommendations aimed at reducing morbidity and mortality in patients with COVID-19.

La pandemia COVID-19 provocada por el betacoronavirus SARS-CoV-2 exige rápidas respuestas desde el campo de la medicina. El riesgo de tromboembolismo venoso y arterial está aumentado durante la infección, especialmente en pacientes críticos. En ese contexto se destaca una coagulopatía caracterizada por niveles elevados de dímero D, con tendencia a la falla multiorgánica, y aumento de la mortalidad. Esas anormalidades de la hemostasia responden a varios mecanismos que deben tenerse en cuenta para la toma de decisiones terapéuticas. Analizamos la evidencia científica disponible en la que se fundamenta el enfoque terapéutico de la coagulopatía descripta y sus complicaciones, con el objetivo de diseñar recomendaciones terapéuticas realistas tendientes a disminuir la morbilidad y la mortalidad en pacientes con COVID-19.

Keywords: COVID-19; cytokine storm; disseminated intravascular coagulation; heparin; sepsis induced coagulopathy; thromboembolism.

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