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Review
. 2021 Jan:99:168-176.
doi: 10.1016/j.reprotox.2020.10.005. Epub 2020 Oct 10.

Intrauterine growth restriction: Clinical consequences on health and disease at adulthood

J B Armengaud  1 , C Yzydorczyk  2 , B Siddeek  2 , A C Peyter  3 , U Simeoni  4
Affiliations
Free article
Review

Intrauterine growth restriction: Clinical consequences on health and disease at adulthood

J B Armengaud et al. Reprod Toxicol. 2021 Jan.
Free article

Abstract

Intrauterine growth restriction (IUGR) affects 10-15% of all pregnancies worldwide. IUGR may result from maternal, placental or fetal origin. Maternal malnutrition before and during pregnancy represents the most prevalent non-genetic or placental cause. IUGR reflects an abnormal adaptive fetal growth in a deleterious environment. Individuals born after IUGR are more susceptible to develop diseases related to subsequent stressors through a lifetime. Animal models help to decipher the underlying causes of dysregulated pathways and molecular modifications conditioning health and disease in adult offspring born after IUGR. The aim of this review is to summarize current knowledge on long term consequences of IUGR, integrating animal models and human studies for a better care of IUGR-born individuals in a life course perspective.

Keywords: DOHaD; IUGR; Life course; Programming.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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