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Review
. 2020 Oct 8;9(10):2253.
doi: 10.3390/cells9102253.

Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Sahar Esfandyari  1 , Rishi Man Chugh  1 , Hang-Soo Park  1 , Elie Hobeika  2 , Mara Ulin  1 , Ayman Al-Hendy  1   3
Affiliations
Review

Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Sahar Esfandyari et al. Cells. .

Abstract

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.

Keywords: infertility; mesenchymal stem cells (MSCs); reproductive system; stem-cell therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A schematic representation of the most important diseases of female reproductive system (including POF, PCOS, endometriosis, and Asherman syndrome). POF, Premature Ovarian Failure; PCOS, Polycystic Ovary Syndrome.
Figure 2
Figure 2
The association between miRNAs and different MSCs with respect to their effects on the female reproductive system. MSCs, Mesenchymal Stem Cells; BMSCs, Bone Marrow Stromal Cells; AFSCs, Amniotic Fluid Stem Cells; PMSCs, Placenta Mesenchymal Stem Cells; miR, miRNAs, microRNA; GCs, Granulosa Cells; PDCD4, Programmed Cell Death Protein 4; PTEN, Phosphatase and Tensin Homolog; BIM, Bcl-2-Like Protein 11; IRAK1, Interleukin-1 Receptor-Associated Kinase 1; TRAF6, TNF Receptor-Associated Factor 6; BCL2L11, B-Cell Lymphoma 2 Like 11.
See this image and copyright information in PMC

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