Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Oct 10;56(10):527.
doi: 10.3390/medicina56100527.

New Strategies for Treatment of Sepsis

Antonio Mirijello  1 , Alberto Tosoni  2 , On Behalf Of The Internal Medicine Sepsis Study Group
Affiliations
Editorial

New Strategies for Treatment of Sepsis

Antonio Mirijello et al. Medicina (Kaunas). .

Abstract

Sepsis represents a major global health concern and is one of the most feared complications for hospitalized patients, being the cause, directly or indirectly, of about half of all hospital deaths. According to the last definition, sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and defined septic shock as a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities are profound enough to significantly increase mortality. Sepsis is a time-dependent disease and requires a prompt recognition and a standardized treatment. The Special Issue "New Strategies for Treatment of Sepsis" has been thought to connect the experience of physicians involved in the diagnosis, management, and treatment of sepsis at every stage of disease, from emergency departments to general and intensive wards. The focus will be pointed on new approaches to this syndrome, such as early recognition based on clinical features and biomarkers, management in non-ICUs, non-invasive treatment strategies, including non-antimicrobial agents, and, of course, invasive approaches. This Special Issue will highlight the many different facets of sepsis, seen through the eyes of different specialists. We hope to spread the knowledge of a new blueprint for treatment.

Keywords: antimicrobial stewardship; emergency department; immunomodulation; intensive care; internal medicine; micronutrients; organ dysfunction.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Reinhart K., Daniels R., Kissoon N., Machado F.R., Schachter R.D., Finfer S. Recognizing sepsis as a global health priority—A WHO resolution. N. Engl. J. Med. 2017;377:414–417. doi: 10.1056/NEJMp1707170. - DOI - PubMed
    1. Rudd K.E., Johnson S.C., Agesa K.M., Shackelford K.A., Tsoi D., Kievlan D.R., Colombara D.V., Ikuta K.S., Kissoon N., Finfer S., et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: Analysis for the Global Burden of Disease Study. Lancet. 2020;395:200–211. doi: 10.1016/S0140-6736(19)32989-7. - DOI - PMC - PubMed
    1. Singer M., Deutschman C.S., Seymour C.W., Shankar-Hari M., Annane D., Bauer M., Bellomo R., Bernard G.R., Chiche J.D., Coopersmith C.M., et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3) JAMA. 2016;315:801–810. doi: 10.1001/jama.2016.0287. - DOI - PMC - PubMed
    1. Zaccone V., Tosoni A., Passaro G., Vallone C.V., Impagnatiello M., Li Puma D.D., De Cosmo S., Landolfi R., Mirijello A., Internal Medicine Sepsis Study Group Sepsis in Internal Medicine wards: Current knowledge, uncertainties and new approaches for management optimization. Ann. Med. 2017;49:582–592. doi: 10.1080/07853890.2017.1332776. - DOI - PubMed
    1. Mirijello A., Tosoni A., Zaccone V., Impagnatiello M., Passaro G., Vallone C.V., Cossari A., Ventura G., Gambassi G., De Cosmo S., et al. MEDS score and vitamin D status are independent predictors of mortality in a cohort of Internal Medicine patients with microbiological identified sepsis. Eur. Rev. Med Pharmacol. Sci. 2019;23:4033–4043. doi: 10.26355/eurrev_201905_17834. - DOI - PubMed

Publication types