Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jan;27(1):327-329.
doi: 10.3201/eid2701.203515. Epub 2020 Oct 13.

Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection

Pyoeng Gyun Choe, Chang Kyung Kang, Hyeon Jeong Suh, Jongtak Jung, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Wan Beom Park, Myoung-Don Oh

Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection

Pyoeng Gyun Choe et al. Emerg Infect Dis. 2021 Jan.

Abstract

We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic persons and 11 patients with pneumonia. The geometric mean titer of neutralizing antibodies declined from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response.

Keywords: 2019 novel coronavirus disease; COVID-19; ELISA; SARS-CoV-2; antibodies; coronavirus; coronavirus disease; neutralizing antibodies; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; waning immunity; zoonoses.

PubMed Disclaimer

Figures

Figure
Figure
Waning antibody response against severe acute respiratory virus coronavirus 2, South Korea, 2020. Responses measured by A) ELISA optical density measurements (p = 0.01); B) neutralizing antibody titers (p = 0.03). Each line indicates data from a single patient.
See this image and copyright information in PMC

References

    1. Choe PG, Kang CK, Suh HJ, Jung J, Kang E, Lee SY, et al. Antibody responses to SARS-CoV-2 at 8 weeks postinfection in asymptomatic patients. Emerg Infect Dis. 2020;26:2484–7. 10.3201/eid2610.202211 - DOI - PMC - PubMed
    1. Long QX, Tang XJ, Shi QL, Li Q, Deng HJ, Yuan J, et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med. 2020;26:1200–4. 10.1038/s41591-020-0965-6 - DOI - PubMed
    1. Kang E, Lee SY, Jung H, Kim MS, Cho B, Kim YS. Operating protocols of a community treatment center for isolation of patients with coronavirus disease, South Korea. Emerg Infect Dis. 2020;26:2329–37. 10.3201/eid2610.201460 - DOI - PMC - PubMed
    1. Choe PG, Kang EK, Lee SY, Oh B, Im D, Lee HY, et al. Selecting coronavirus disease 2019 patients with negligible risk of progression: early experience from non-hospital isolation facility in Korea. Korean J Intern Med (Korean Assoc Intern Med). 2020;35:765–70. 10.3904/kjim.2020.159 - DOI - PMC - PubMed
    1. Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA. 2020;323:1582–9. 10.1001/jama.2020.4783 - DOI - PMC - PubMed

Publication types