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. 2021 Mar;45(3):799-807.
doi: 10.1007/s00268-020-05814-6. Epub 2020 Oct 13.

Determinants of Breast-Conserving Therapy in the Asian Population: A Systematic Review

Maria Paz Galeano Machuca  1 , Shelly Chien-Chien Cheng  2 , Tony Hong-Ting Jou  3 , Chih-Tao Cheng  4   5
Affiliations

Determinants of Breast-Conserving Therapy in the Asian Population: A Systematic Review

Maria Paz Galeano Machuca et al. World J Surg. 2021 Mar.

Abstract

Background: Treatment guidelines recommend breast-conserving therapy (BCT) for patients with early-stage breast cancer. However, Asian patients choose mastectomy over BCT, and the factors influencing this choice are unknown. This review aimed to identify the factors most frequently reported in the Eastern and Southeastern Asian population influencing the choice of BCT for treatment of early-stage breast cancer.

Methods: PRISMA guidelines were followed, and PubMed and EMBASE databases were used. The literature search initially identified 4619 articles; abstract screening and full-text screening were performed on 150 and 19 articles, respectively, and 9 articles were finally included in the study.

Results: Selection of BCT was associated with sociodemographic factors, such as high socioeconomic status and education level and young age at diagnosis; clinicopathological factors, such as small tumor size and mammographically detected tumors; and healthcare provider factors, such as treatment from a female doctor or from a breast specialist. However, not selecting BCT was associated with personal factors, such as fear of recurrence and avoidance of further treatment.

Conclusions: The process of making a treatment decision is complicated and involves many factors influencing patients' choice of surgery type. Exploring these factors helps to elucidate why patients do not choose BCT as their treatment option.

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References

    1. Veronesi U, Cascinelli N, Mariani L et al (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347:1227–1232 - DOI
    1. Arriagada R, Le MG, Rochard F et al (1996) Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. institut gustave-roussy breast cancer group. J Clin Oncol 14:1558–1564. https://doi.org/10.1200/JCO.1996.14.5.1558 - DOI - PubMed
    1. Blichert-Toft M, Rose C, Andersen J et al (1992) Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. J Natl Cancer Inst Monogr 11:19–25
    1. Jacobson JA, Danforth DN, Cowan KH et al (1995) Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 332:907–911 - DOI
    1. van Dongen JA, Voogd AC, Fentiman IS et al (2000) Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial. J Natl Cancer Inst 92:1143–1150 - DOI

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