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Case Reports
. 2020 Sep 7;12(9):e10301.
doi: 10.7759/cureus.10301.

Gamma-Delta T-Cell Lymphoma Following Allogeneic Stem Cell Transplant for Primary Myelofibrosis

Robert Hoard  1 , George Shahin  2 , Florin D Andreca  3 , Michael Osswald  4
Affiliations
Case Reports

Gamma-Delta T-Cell Lymphoma Following Allogeneic Stem Cell Transplant for Primary Myelofibrosis

Robert Hoard et al. Cureus. .

Abstract

Primary myelofibrosis (PMF) is a disease that affects the bone marrow. It presents with cytopenias, hepatospleomegaly accompanied with extramedullary hematopoiesis, and often with constitutional symptoms. Cytotoxic gamma-delta T-cells are considered a distinct hepatosplenic lymohoma. This is a case presentation of a 43-year-old male with an initial diagnosis of PMF who underwent allogeneic stem cell transplantation complicated by primary graft failure. He subsequently underwent a partial splenic embolization; however, he quickly developed a fulminant hepatosplenic gamma-delta T-cell lymphoma which led to his death that was diagnosed posthumously. PMF has been known to transform into an acute myeloid leukemia, but there has been no established link with gamma-delta T-cell lymphoma.

Keywords: gamma-delta t-cell; lymohoma; myelofibrosis.

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Conflict of interest statement

The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, U.S. Army Institute of Surgical Research, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, the Department of the Air Force, or the Department of Defense or the U.S. Government.

Figures

Figure 1
Figure 1. Pretransplant splenomegaly.
Figure 2
Figure 2. Post-transplant splenomegaly.
Figure 3
Figure 3. Relapsed splenomegaly.
Figure 4
Figure 4. Postembolization spleen.
Figure 5
Figure 5. Peripheral smear.
Figure 6
Figure 6. Peripheral blood flow cytometry results.
See this image and copyright information in PMC

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