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Review
. 2020 Oct 12;21(20):7504.
doi: 10.3390/ijms21207504.

DNA Damage Response and Immune Defense

Claudia Nastasi  1 , Laura Mannarino  1 , Maurizio D'Incalci  1
Affiliations
Review

DNA Damage Response and Immune Defense

Claudia Nastasi et al. Int J Mol Sci. .

Abstract

DNA damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn, coordinates DNA damage checkpoint activation and promotes the removal of DNA lesions. In recent years, several studies have shown how the DDR and the immune system are tightly connected, revealing an important crosstalk between the two of them. This interesting interplay has opened up new perspectives in clinical studies for immunological diseases as well as for cancer treatment. In this review, we provide an overview, from cellular to molecular pathways, on how DDR and the immune system communicate and share the crucial commitment of maintaining the genomic fitness.

Keywords: DNA damage response; DNA repair; cancer; immune defense; immune signalling; innate immunity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
DNA sensing and activation of immune signaling.
See this image and copyright information in PMC

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