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. 2020 Oct 14;12(1):129.
doi: 10.1186/s13195-020-00700-8.

Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD

Federica Cacciamani  1   2   3   4   5 , Luisa Sambati  6   7 , Marion Houot  1   4   8 , Marie-Odile Habert  9   10 , Bruno Dubois  1   4   8 , Stéphane Epelbaum  11   12   13   14   15   16 ; INSIGHT-PreAD study group
Collaborators, Affiliations

Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD

Federica Cacciamani et al. Alzheimers Res Ther. .

Abstract

Background: Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer's disease (AD). Recent studies showed that ACD can also be reduced in the early stages.

Methods: We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores' evolution and the association between longitudinal changes in ACD and in cognitive score.

Results: 76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ACD, had significantly higher amyloid burden than the reference class, and were mostly men. We found no overall effect of baseline ACD on cognitive scores' evolution and no association between longitudinal changes in ACD and in cognitive scores.

Conclusions: ACD begins to decrease during the preclinical phase in a group of individuals, who are of great interest and need to be further characterized.

Trial registration: The present study was conducted as part of the INSIGHT-PreAD study. The identification number of INSIGHT-PreAD study (ID-RCB) is 2012-A01731-42.

Keywords: Amyloid; Awareness; Brain; Cognitive decline; Preclinical Alzheimer’s disease.

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Conflict of interest statement

Federica Cacciamani reports no disclosures.

Luisa Sambati reports no disclosures.

Marion Houot reports no disclosures.

Marie-Odile Habert has received speaker honoraria from Lilly, GE Healthcare, and Piramal.

Bruno Dubois has received consultancy fees from Biogen, Boehringer Ingelheim, Eli Lilly, and MedAvante and grants for his institution from Merck, Pfizer, and Roche.

Stéphane Epelbaum reports receiving fees from Roche, Eli Lilly, Biogen, and GE Healthcare as a consultant or advisory board member.

Figures

Fig. 1
Fig. 1
Sample selection for the three objectives
Fig. 2
Fig. 2
Trajectories of the subjects’ and informants’ HABC-M scores in the whole sample
Fig. 3
Fig. 3
Evolution of the ACDI across the 36 months of study in the three classes of subjects identified by the LCLMM (objective 1)
See this image and copyright information in PMC

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