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Review
. 2021 Jan;47(1):90-93.
doi: 10.1007/s00134-020-06273-2. Epub 2020 Oct 14.

Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview

Michael J Carter  1   2 , Manu Shankar-Hari  3   4 , Shane M Tibby  5   6
Affiliations
Review

Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview

Michael J Carter et al. Intensive Care Med. 2021 Jan.
No abstract available

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
A PIMS-TS clinical features (mean value from published cohorts, August 2020).  B Prevalence of clinical features across cohorts of PIMS-TS, Kawasaki disease and toxic shock syndrome. “Cardiac” and “Respiratory” refer to signs and symptoms of respective organ system involvement, whilst “Ventilation” and “Vasoactives” refer to types of organ support. C Proposed mechanisms for PIMS-TS disease, including altered interferon signalling, failure to clear SARS-CoV-2 and resultant cytokine excess leading to excess inflammation; or, antibody-mediated disease including potential autoantibodies or antibody-dependent enhancement of disease by enhanced viral invasion of host cells
See this image and copyright information in PMC

References

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    1. Whittaker E, Bamford A, Kenny J, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020;324:259–269. doi: 10.1001/jama.2020.10369. - DOI - PMC - PubMed

Publication types

Supplementary concepts