Atypical Diabetes Presentations in Sub-Saharan Africa Classification Puzzle and Possible Role of Precision Medicine

Abstract

Precision in the diagnosis and classification of diabetes mellitus, a complex heterogeneous disease is increasingly required to achieve treatment goals and prevent complications. Several reviews over decades have not completely solved the diabetes classification puzzle. African clinicians are sometimes confronted with the difficulty of classifying a newly diagnosed diabetes patient presenting atypically. These unusual presentations fall into those with diagnosis of either clinical type 1 or 2 diabetes but having some diagnostic and/or therapeutic features at variance with what are seen in the Western nations, those with tropical diabetes and those known as ketosis-prone type 2 diabetes (KPD). Reports from many African countries indicate that patients do not fit the classic pattern seen in the Western nations. In recent times, there has been groundswell of pressures and proposed models to evolve a more accurate classification of diabetes and the recent 2019 WHO diabetes classification seems to have acknowledged and accommodated these concerns. Perhaps advances in genomic knowledge could help with precision in diabetes classification, especially in Africa. This review seeks to highlight the challenges often encountered with classifying diabetes patients in Africa, and proffer suggestions on the way forward including possible benefit from advances in molecular genomics.