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Comment
. 2021 Mar;73(3):1227-1229.
doi: 10.1002/hep.31596. Epub 2021 Feb 21.

Chimeric Antigen Receptor T Cells as Senolytic and Antifibrotic Therapy

Aashreya Ravichandra  1 , Aveline Filliol  1 , Robert F Schwabe  1   2
Affiliations
Comment

Chimeric Antigen Receptor T Cells as Senolytic and Antifibrotic Therapy

Aashreya Ravichandra et al. Hepatology. 2021 Mar.
No abstract available

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Comment on

  • Senolytic CAR T cells reverse senescence-associated pathologies.
    Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW. Amor C, et al. Nature. 2020 Jul;583(7814):127-132. doi: 10.1038/s41586-020-2403-9. Epub 2020 Jun 17. Nature. 2020. PMID: 32555459 Free PMC article.

References

    1. Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso‐Curbelo D, et al. Senolytic CAR T cells reverse senescence‐associated pathologies. Nature 2020;583:127‐132.
    1. Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008;134:657‐667.
    1. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH, Brenner D. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology 2003;37:653‐664.
    1. Coppe JP, Desprez PY, Krtolica A, Campisi J. The senescence‐associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010;5:99‐118.
    1. Schultz L, Mackall C. Driving CAR T cell translation forward. Sci Transl Med 2019;11:eaaw2127.

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