What causes hidradenitis suppurativa ?-15 years after

doi:10.1111/exd.14214

Review

. 2020 Dec;29(12):1154-1170.

doi: 10.1111/exd.14214.

What causes hidradenitis suppurativa ?-15 years after

Christos C Zouboulis^{1

2}, Farida Benhadou^{1

3}, Angel S Byrd⁴, Nisha S Chandran^{1

5}, Evangelos J Giamarellos-Bourboulis^{1

6}, Gabriella Fabbrocini^{1

7}, John W Frew⁸, Hideki Fujita⁹, Marcos A González-López^{1

10}, Philippe Guillem^{1

11}, Wayne P F Gulliver^{1

12}, Iltefat Hamzavi¹³, Yildiz Hayran¹⁴, Barbara Hórvath^{1

15}, Sophie Hüe¹⁶, Robert E Hunger^{1

17}, John R Ingram^{1

18}, Gregor B E Jemec^{1

19}, Qiang Ju^{1

20}, Alexa B Kimball²¹, Joslyn S Kirby²², Maria P Konstantinou²³, Michelle A Lowes⁸, Amanda S MacLeod²⁴, Antonio Martorell^{1

25}, Angelo V Marzano^{1

26

27}, Łukasz Matusiak^{1

28}, Aude Nassif^{1

29}, Elena Nikiphorou³⁰, Georgios Nikolakis^{1

2}, André Nogueira da Costa^{1

31}, Martin M Okun³², Lauren A V Orenstein³³, José Carlos Pascual^{1

34}, Ralf Paus^{1

35}, Benjamin Perin³⁶, Errol P Prens^{1

37}, Till A Röhn³⁸, Andrea Szegedi³⁹, Jacek C Szepietowski^{1

28}, Thrasyvoulos Tzellos^{1

40}, Baoxi Wang^{1

41}, Hessel H van der Zee^{1

37}

Affiliations

¹ European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.
² Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.
³ Department of Dermatology, Hôpital Erasme, Universite Libre de Bruxelles, Bruxelles, Belgium.
⁴ Department of Dermatology, Howard University College of Medicine, Washington, DC, USA.
⁵ Division of Dermatology, Department of Medicine, National University Hospital, Singapore.
⁶ 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
⁷ Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
⁸ The Rockefeller University, New York, NY, USA.
⁹ Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan.
¹⁰ Division of Dermatology, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Spain.
¹¹ Department of Surgery, Clinique du Val d'Ouest (Lyon), ResoVerneuil (Paris) and Groupe de Recherche en Proctologie de la Société Nationale Française de ColoProctologie, Paris, France.
¹² Faculty of Medicine, Memorial University of Newfoundland, and NewLab Clinical Research Inc, St. John's, Canada.
¹³ Department of Dermatology, Henry Ford Hospital, Wayne State University, Detroit, MI, USA.
¹⁴ Department of Dermatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
¹⁵ Department of Dermatology University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
¹⁶ INSERM, Créteil, France.
¹⁷ Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
¹⁸ Department of Dermatology & Academic Wound Healing, Division of Infection and Immunity, Cardiff University, Cardiff, UK.
¹⁹ Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
²⁰ Department of Dermatology, RenJi Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
²¹ Department of Dermatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
²² Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
²³ Dermatology Department, Paul Sabatier University, University Hospital of Toulouse, Toulouse, France.
²⁴ Department of Dermatology, Department of Immunology, Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
²⁵ Department of Dermatology, Hospital of Manises, Valencia, Spain.
²⁶ Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁷ Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
²⁸ Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.
²⁹ Institut Pasteur, Paris, France.
³⁰ Centre for Rheumatic Diseases, King's College London, and Department of Rheumatology, King's College Hospital, London, UK.
³¹ Translational Science and Experimental Medicine, Early Respiratory and Immunology, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
³² Fort HealthCare, Fort Atkinson, WI, USA.
³³ Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.
³⁴ Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.
³⁵ Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
³⁶ Division of Dermatology, University of Washington, Seattle, WA, USA.
³⁷ Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
³⁸ Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
³⁹ Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
⁴⁰ Department of Dermatology, Nordland Hospital Trust, Bodø, Norway.
⁴¹ Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

PMID: 33058306
DOI: 10.1111/exd.14214

Free article

Review

What causes hidradenitis suppurativa ?-15 years after

Christos C Zouboulis et al. Exp Dermatol. 2020 Dec.

Free article

. 2020 Dec;29(12):1154-1170.

doi: 10.1111/exd.14214.

Authors

Affiliations

¹ European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.
² Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.
³ Department of Dermatology, Hôpital Erasme, Universite Libre de Bruxelles, Bruxelles, Belgium.
⁴ Department of Dermatology, Howard University College of Medicine, Washington, DC, USA.
⁵ Division of Dermatology, Department of Medicine, National University Hospital, Singapore.
⁶ 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
⁷ Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
⁸ The Rockefeller University, New York, NY, USA.
⁹ Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan.
¹⁰ Division of Dermatology, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Spain.
¹¹ Department of Surgery, Clinique du Val d'Ouest (Lyon), ResoVerneuil (Paris) and Groupe de Recherche en Proctologie de la Société Nationale Française de ColoProctologie, Paris, France.
¹² Faculty of Medicine, Memorial University of Newfoundland, and NewLab Clinical Research Inc, St. John's, Canada.
¹³ Department of Dermatology, Henry Ford Hospital, Wayne State University, Detroit, MI, USA.
¹⁴ Department of Dermatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
¹⁵ Department of Dermatology University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
¹⁶ INSERM, Créteil, France.
¹⁷ Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
¹⁸ Department of Dermatology & Academic Wound Healing, Division of Infection and Immunity, Cardiff University, Cardiff, UK.
¹⁹ Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
²⁰ Department of Dermatology, RenJi Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
²¹ Department of Dermatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
²² Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
²³ Dermatology Department, Paul Sabatier University, University Hospital of Toulouse, Toulouse, France.
²⁴ Department of Dermatology, Department of Immunology, Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
²⁵ Department of Dermatology, Hospital of Manises, Valencia, Spain.
²⁶ Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁷ Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
²⁸ Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.
²⁹ Institut Pasteur, Paris, France.
³⁰ Centre for Rheumatic Diseases, King's College London, and Department of Rheumatology, King's College Hospital, London, UK.
³¹ Translational Science and Experimental Medicine, Early Respiratory and Immunology, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
³² Fort HealthCare, Fort Atkinson, WI, USA.
³³ Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.
³⁴ Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.
³⁵ Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
³⁶ Division of Dermatology, University of Washington, Seattle, WA, USA.
³⁷ Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
³⁸ Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
³⁹ Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
⁴⁰ Department of Dermatology, Nordland Hospital Trust, Bodø, Norway.
⁴¹ Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

PMID: 33058306
DOI: 10.1111/exd.14214

Abstract

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy." (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as "the only inflammatory skin disease than can be healed". This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future.

Keywords: acne inversa; hair follicle; hidradenitis suppurativa; inflammatory skin diseases; pathogenesis.

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References

REFERENCES

1. Kurzen H, Kurokawa I, Jemec GBE, et al. Exp Dermatol. 2008;17:455.
1. Garg A, Neuren E, Cha D, et al. J Am Acad Dermatol. 2020;82:366.
1. Reddy S, Strunk A, Garg A. JAMA Dermatol. 2019;155:797.
1. Zouboulis CC, Nogueira da Costa A, Makrantonaki E, et al. J Eur Acad Dermatol Venereol. 2020;34:846.
1. Duchatelet S, Miskinyte S, Delage M, et al. J Invest Dermatol. 2020;140:2085.

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[1] Kurzen H, Kurokawa I, Jemec GBE, et al. Exp Dermatol. 2008;17:455.

[2] Kurzen H, Kurokawa I, Jemec GBE, et al. Exp Dermatol. 2008;17:455.

[3] Garg A, Neuren E, Cha D, et al. J Am Acad Dermatol. 2020;82:366.

[4] Garg A, Neuren E, Cha D, et al. J Am Acad Dermatol. 2020;82:366.

[5] Reddy S, Strunk A, Garg A. JAMA Dermatol. 2019;155:797.

[6] Reddy S, Strunk A, Garg A. JAMA Dermatol. 2019;155:797.

[7] Zouboulis CC, Nogueira da Costa A, Makrantonaki E, et al. J Eur Acad Dermatol Venereol. 2020;34:846.

[8] Zouboulis CC, Nogueira da Costa A, Makrantonaki E, et al. J Eur Acad Dermatol Venereol. 2020;34:846.

[9] Duchatelet S, Miskinyte S, Delage M, et al. J Invest Dermatol. 2020;140:2085.

[10] Duchatelet S, Miskinyte S, Delage M, et al. J Invest Dermatol. 2020;140:2085.

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What causes hidradenitis suppurativa ?-15 years after

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What causes hidradenitis suppurativa ?-15 years after

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