Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug;36(Suppl 2):190-193.
doi: 10.1007/s12055-020-00971-8. Epub 2020 Jun 22.

ABO-incompatible heart transplantation in children-a systematic review of current practice

Arun Beeman  1 , Nagarajan Muthialu  1
Affiliations
Review

ABO-incompatible heart transplantation in children-a systematic review of current practice

Arun Beeman et al. Indian J Thorac Cardiovasc Surg. 2020 Aug.

Abstract

Pediatric heart transplantation has significantly improved in the survival of children with cardiomyopathy and/or complex congenital heart defects. With the increasing number of children needing transplantation, there is a growing demand for the organ, making it harder to cope with the increasing number of children on the waiting list. One of the advances that helped reduce the waiting list mortality significantly is the ability to transplant children from donors with ABO incompatibility. Modification of perfusion abilities and management of donor organ improves outcome in this select population, making ABO-incompatible transplantation an attractive option in the wider armamentarium available for pushing boundaries in these children without impacting on outcomes.

Keywords: ABO incompatibility; Cardiomyopathy; Cardiopulmonary bypass; Heart transplantation.

PubMed Disclaimer

Conflict of interest statement

Conflict of interestThe authors declare that there is no conflict of interest.

References

    1. Rossano JW, Singh TP, Cherikh WS,et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report – 2019; Focus theme: Donor and recipient size match. J Heart Lung Transplant. 2019;38:1028–1041 - PMC - PubMed
    1. Almond CSD, Thiagarajan RR, Piercey GE, et al. Waiting list mortality among children listed for heart transplantation in the United States. Circulation. 2009;119:717–727. doi: 10.1161/CIRCULATIONAHA.108.815712. - DOI - PMC - PubMed
    1. Shimizu M, Nishinaka T, Inai K, Nakanishi T. Outcomes in children with advanced heart failure in Japan: importance of mechanical circulatory support. Heart Vessel. 2016;31:1162–1167. doi: 10.1007/s00380-015-0722-9. - DOI - PubMed
    1. Shi WY, Rouse M, Weintraub RG, et al. Predictors of outcomes in children awaiting heart transplantation: an experience from a National Paediatric Heart Transplantation Programme. Eur J Cardio Thorac Surg. 2016;49:1711–1718. doi: 10.1093/ejcts/ezv465. - DOI - PubMed
    1. Smits JM, Thul J, De Pauw M, et al. Pediatric heart allocation and transplantation in Eurotransplant. Transpl Int. 2014;27:917–925. doi: 10.1111/tri.12356. - DOI - PubMed

LinkOut - more resources