Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 25:2020:6209841.
doi: 10.1155/2020/6209841. eCollection 2020.

Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy

Łukasz Kapek  1   2 , Justyna Paprocka  3 , Marek Kijonka  1 , Maria Zych  4 , Ewa Emich-Widera  3 , Beata Rzepka-Migut  5 , Damian Borys  6 , Ilona Kaczmarczyk-Sedlak  4 , Maria Sokół  1
Affiliations

Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy

Łukasz Kapek et al. Int J Endocrinol. .

Abstract

Purpose: In the present study, the salivary melatonin secretion in the hypoxic ischemic encephalopathy (HIE) children was measured. The logit model was fitted to the data to obtain the salivary dim light melatonin onsets (DLMOs), and the results were compared with the values estimated from the classic threshold method with a linear interpolation and those previously published for the blood measurements.

Materials and methods: 9 patients suffering from HIE aged from 65 to 80 months were included in the study. The melatonin levels were assessed by a radioimmunoassay (RIA). The diurnal melatonin secretion was estimated using a nonlinear least squares method. Student's t-test and the Mann-Whitney U test were used for the comparisons of the obtained parameters.

Results: The circadian profiles of the melatonin secretion for both calculation methods do not differ statistically. The DLMO parameters obtained in the blood and saliva samples in children with hypoxic ischemic encephalopathy were similar.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
The melatonin secretion model. The solid line shows the curve-shaped function approximating the melatonin secretion with the following parameters: b1 is the melatonin release amplitude; b2 is DLMO50E; b3 is the minimum melatonin concentration; and dotted line is the minimum melatonin concentration level.
Figure 2
Figure 2
The salivary melatonin onset for the exemplary patient with hypoxic ischemic encephalopathy—the estimated model; and ο are the measured values.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Tordjman S., Chokron S., Delorme R., et al. Melatonin: pharmacology, functions and therapeutic benefits. Current Neuropharmacology. 2017;15(3):434–443. doi: 10.2174/1570159x14666161228122115. - DOI - PMC - PubMed
    1. Benloucif S., Burgess H. J., Klerman E. B., et al. Measuring melatonin in humans. Journal of Clinical Sleep Medicine. 2008;4(1):66–69. doi: 10.5664/jcsm.27083. - DOI - PMC - PubMed
    1. Paprocka J., Kijonka M., Sokół M. Drăgoi C. M., Nicolae A. C. Melatonin in Childhood Epilepsy and in Child Neurology”, Melatonin-Molecular Biology, Clinical and Pharmaceutical Approaches. London, UK: IntechOpen; 2018. - DOI
    1. Paprocka J., Kijonka M., Pęcka M., Sokół M. Melatonin in epilepsy: a new mathematical model of diurnal secretion. International Journal of Endocrinology. 2016;2016:8. doi: 10.1155/2016/3861461.3861461 - DOI - PMC - PubMed
    1. Paprocka J., Kijonka M., Borys D., Emich-Widera E, Wojcieszek P, Sokół M. Mathematical evaluation of melatonin secretion in hypoxic ischemic encephalopathy. Neuro Endocrinology Letters. 2018;39(5):391–400. - PubMed

LinkOut - more resources