Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum

doi:10.1155/2020/6489648

Review

. 2020 Sep 30:2020:6489648.

doi: 10.1155/2020/6489648. eCollection 2020.

Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum

He-Shui Yu^{1

2}, Lin-Lin Wang³, Ying He³, Li-Feng Han², Hui Ding¹, Xin-Bo Song^{1

4}, Xiu-Mei Gao², Nai-Ru Yun³, Zheng Li^{1

2}

Affiliations

¹ College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
² Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
³ Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China.
⁴ Tianjin Modern Innovative TCM Technology Co., Ltd., Tianjin 300000, China.

PMID: 33062019
PMCID: PMC7545463
DOI: 10.1155/2020/6489648

Review

Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum

He-Shui Yu et al. Evid Based Complement Alternat Med. 2020.

. 2020 Sep 30:2020:6489648.

doi: 10.1155/2020/6489648. eCollection 2020.

Authors

He-Shui Yu^{1

2}, Lin-Lin Wang³, Ying He³, Li-Feng Han², Hui Ding¹, Xin-Bo Song^{1

4}, Xiu-Mei Gao², Nai-Ru Yun³, Zheng Li^{1

2}

Affiliations

¹ College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
² Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
³ Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China.
⁴ Tianjin Modern Innovative TCM Technology Co., Ltd., Tianjin 300000, China.

PMID: 33062019
PMCID: PMC7545463
DOI: 10.1155/2020/6489648

Abstract

The roots of Polygonum multiflorum (PM) (He Shou Wu in Chinese) are one of the most commonly used tonic traditional Chinese medicines (TCMs) in China. PM is traditionally valued for its antiaging, liver- and kidney-tonifying, and hair-blackening effects. However, an increasing number of hepatotoxicity cases induced by PM attract the attention of scholars worldwide. Thus far, the potential liver injury compounds and the mechanism are still uncertain. The aim of this review is to provide comprehensive information on the potential hepatotoxic components and mechanism of PM based on the scientific literature. Moreover, perspectives for future investigations of hepatotoxic components are discussed. This study will build a new foundation for further study on the hepatotoxic components and mechanism of PM.

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Conflict of interest statement

The authors declare that they have no conflicts of interest regarding the publication of this paper.

Figures

**Figure 1**
The structures of potential hepatotoxic compounds in PM.

See this image and copyright information in PMC

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References

1. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Vol. 1. Beijing: Chemical Industry Press; 2020.
1. Ho T.-T., Murthy H. N., Dalawai D., Bhat M. A., Paek K.-Y., Park S.-Y. Attributes of Polygonum multiflorum to transfigure red biotechnology. Applied Microbiology and Biotechnology. 2019;103(8):3317–3326. doi: 10.1007/s00253-019-09709-y. - DOI - PubMed
1. Lin L., Ni B., Lin H., et al. Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review. Journal of Ethnopharmacology. 2015;159:158–183. doi: 10.1016/j.jep.2014.11.009. - DOI - PMC - PubMed
1. Dong H., Slain D., Cheng J., Ma W., Liang W. Eighteen cases of liver injury following ingestion of Polygonum multiflorum. Complementary Therapies in Medicine. 2014;22(1):70–74. doi: 10.1016/j.ctim.2013.12.008. - DOI - PubMed
1. Jung K. A., Min H. J., Yoo S. S., et al. Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum thunb. Gut and Liver. 2011;5(4):493–499. doi: 10.5009/gnl.2011.5.4.493. - DOI - PMC - PubMed

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[1] Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Vol. 1. Beijing: Chemical Industry Press; 2020.

[2] Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Vol. 1. Beijing: Chemical Industry Press; 2020.

[3] Ho T.-T., Murthy H. N., Dalawai D., Bhat M. A., Paek K.-Y., Park S.-Y. Attributes of Polygonum multiflorum to transfigure red biotechnology. Applied Microbiology and Biotechnology. 2019;103(8):3317–3326. doi: 10.1007/s00253-019-09709-y. - DOI - PubMed

[4] Ho T.-T., Murthy H. N., Dalawai D., Bhat M. A., Paek K.-Y., Park S.-Y. Attributes of Polygonum multiflorum to transfigure red biotechnology. Applied Microbiology and Biotechnology. 2019;103(8):3317–3326. doi: 10.1007/s00253-019-09709-y. - DOI - PubMed

[5] Lin L., Ni B., Lin H., et al. Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review. Journal of Ethnopharmacology. 2015;159:158–183. doi: 10.1016/j.jep.2014.11.009. - DOI - PMC - PubMed

[6] Lin L., Ni B., Lin H., et al. Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review. Journal of Ethnopharmacology. 2015;159:158–183. doi: 10.1016/j.jep.2014.11.009. - DOI - PMC - PubMed

[7] Dong H., Slain D., Cheng J., Ma W., Liang W. Eighteen cases of liver injury following ingestion of Polygonum multiflorum. Complementary Therapies in Medicine. 2014;22(1):70–74. doi: 10.1016/j.ctim.2013.12.008. - DOI - PubMed

[8] Dong H., Slain D., Cheng J., Ma W., Liang W. Eighteen cases of liver injury following ingestion of Polygonum multiflorum. Complementary Therapies in Medicine. 2014;22(1):70–74. doi: 10.1016/j.ctim.2013.12.008. - DOI - PubMed

[9] Jung K. A., Min H. J., Yoo S. S., et al. Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum thunb. Gut and Liver. 2011;5(4):493–499. doi: 10.5009/gnl.2011.5.4.493. - DOI - PMC - PubMed

[10] Jung K. A., Min H. J., Yoo S. S., et al. Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum thunb. Gut and Liver. 2011;5(4):493–499. doi: 10.5009/gnl.2011.5.4.493. - DOI - PMC - PubMed

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Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum

Affiliations

Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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References

Publication types

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