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Case Reports
. 2020 Sep 3:37:11.
doi: 10.11604/pamj.2020.37.11.24494. eCollection 2020.

Simultaneous bilateral spontaneous pneumothorax as the first manifestation of primary pulmonary MALT lymphoma

Asma Migaou  1 , Nader Slama  2 , Manel Njima  3 , Asma Achour  4 , Ahmed Ben Saad  1 , Sarra Boukhris  2 , Nesrine Fahem  1 , Sabrine Dimassi  2 , Adnene Laatiri  2 , Saoussen Cheikh Mhammed  1 , Naceur Rouatbi  1 , Sameh Joobeur  1
Affiliations
Case Reports

Simultaneous bilateral spontaneous pneumothorax as the first manifestation of primary pulmonary MALT lymphoma

Asma Migaou et al. Pan Afr Med J. .

Abstract

Primary pulmonary lymphoma is a rare entity. Furthermore, simultaneous bilateral spontaneous pneumothorax (SBSP) is a very rare condition which is often related to therapeutic complications. We present, to the best of our knowledge, the first case of primary pulmonary mucosa associated lymphoid tissue (MALT) lymphoma revealed by SBSP. A 50-year-old female was diagnosed with organizing pneumonia. One month later, she presented with sudden chest pain and shortness of breath due to SBSP. Bilateral chest tubes were inserted. A scan- guided right lung biopsy led to the diagnosis of primary pulmonary MALT lymphoma. The patient was treated with R-CHOP chemotherapy. The association between lymphoma and pneumothorax is extremely rare, often related to therapeutic toxicity. We report the case of SBSP as the first manifestation of primary pulmonary MALT lymphoma.

Keywords: Bilateral pneumothorax; MALT lymphoma; organizing pneumonia; pneumothorax.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
A) bilateral pneumothorax on chest radiograph (arrows); B) chest radiograph after chest tubes removal; C) recurrence of the left pneumothorax
Figure 2
Figure 2
(A+B+C) coronal and (D+E) transverse computed tomography chest scan after bilateral drainage: bilateral pulmonary consolidation associated to bilateral air cysts and bilateral residual pneumothorax
Figure 3
Figure 3
diffuse tumor proliferation of small lymphoid cells resembling mature lymphocytes (A:HEx100, B:HEx400)
Figure 4
Figure 4
positivity of tumor cells for CD20 (A), CD3 (B) and CD5 (C) are negative
See this image and copyright information in PMC

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