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Case Reports
. 2020 Jun 18;7(6):e00409.
doi: 10.14309/crj.0000000000000409. eCollection 2020 Jun.

Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033)

Mary Barbara  1   2 , Sadhna Dhingra  3 , Ayse L Mindikoglu  1   2
Affiliations
Case Reports

Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033)

Mary Barbara et al. ACG Case Rep J. .

Abstract

We report a 52-year-old man who developed drug-induced liver injury after taking Alpha Bolic (contains RAD-140) and Alpha Elite (contains both RAD-140 and LGD-4033) supplements. Liver biopsy demonstrated diffuse centrilobular canalicular cholestasis, prominent ductular reaction, and mild lobular inflammation with rare non-necrotizing epithelioid granuloma suggestive of drug-induced liver injury. Liver enzymes returned to normal levels approximately 3 months after the patient stopped both supplements. We present the mechanism of drug-induced liver injury associated with 2 selective androgen receptor modulators, including RAD-140 and LGD 4033.

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Figures

Figure 1.
Figure 1.
Liver biopsy showing (A) canalicular bile plugs (arrows), (B) portal tract with bile duct damage and cholangiolar proliferation with associated neutrophils, and (C) non-necrotizing epithelioid granuloma (arrows) in the lobule (hematoxylin and eosin, 400×).
See this image and copyright information in PMC

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