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. 2020 Nov 9;38(5):621-623.
doi: 10.1016/j.ccell.2020.10.003. Epub 2020 Oct 15.

Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures

Oula Dagher  1 , Tiffany R King  1 , Nils Wellhausen  1 , Avery D Posey Jr  2
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Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures

Oula Dagher et al. Cancer Cell. .
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Abstract

CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.

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Conflict of interest statement

Declaration of Interests A.D.P. and T.R.K. are inventors on patent applications filed by the University of Pennsylvania related to CAR-T cells. A.D.P. has licensed intellectual property to Novartis and Tmunity Therapeutics. A.D.P. is founder of Cartio Therapeutics and an advisor for GO Therapeutics.

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