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Comparative Study
. 2020 Oct 16;12(20):19867-19879.
doi: 10.18632/aging.103941. Epub 2020 Oct 16.

CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients

Mingming Jin  1 , Nannan Shi  2 , Meng Wang  1 , Chunzi Shi  1 , Shengjie Lu  1 , Qing Chang  3 , Shuang Sha  3 , Yun Lin  4 , Yingmin Chen  3 , Hui Zhou  3 , Kaiyi Liang  3 , Xuyuan Huang  3 , Yuxin Shi  2 , Gang Huang  1
Affiliations
Comparative Study

CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients

Mingming Jin et al. Aging (Albany NY). .

Abstract

The ongoing outbreak of COVID-19 has been announced by the World Health Organization as a worldwide public health emergency. The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients. The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The cut-off value for CD45 was -94.33. The K-values for CD45 in non-severe case were above the cut-off values, indicating a 100% prediction success rate for severe and non-severe cases following SARS-CoV-2 infection. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly for the elderly. CD45 deficiency dysfunction the naïve and memory T lymphocytes which may affects the long-term effectiveness of COVID-19 vaccines. K-values of CD45 might be useful in distinguishing between severe and non-severe cases in the early infection. May be CD45 could increase the diagnostic sensitivity.

Keywords: COVID-19; clinical characteristics; coronavirus disease 2019; immunopathology; pneumonia; severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

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Conflict of interest statement

CONFLICTS OF INTEREST: These authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Albumin expression in COVID-19 patients.
Figure 2
Figure 2
Expression of CRP and hs-CRP in COVID-19 patients.
Figure 3
Figure 3
CD3, CD8, and CD45 counts in COVID-19 patients.
Figure 4
Figure 4
K-values for CD3, CD8, and CD45.
Figure 5
Figure 5
K-value distributions of CD3 and CD45.
See this image and copyright information in PMC

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