Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2020 Oct 16;12(20):19867-19879.
doi: 10.18632/aging.103941. Epub 2020 Oct 16.

CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients

Mingming Jin  1 , Nannan Shi  2 , Meng Wang  1 , Chunzi Shi  1 , Shengjie Lu  1 , Qing Chang  3 , Shuang Sha  3 , Yun Lin  4 , Yingmin Chen  3 , Hui Zhou  3 , Kaiyi Liang  3 , Xuyuan Huang  3 , Yuxin Shi  2 , Gang Huang  1
Affiliations
Comparative Study

CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients

Mingming Jin et al. Aging (Albany NY). .

Abstract

The ongoing outbreak of COVID-19 has been announced by the World Health Organization as a worldwide public health emergency. The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients. The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The cut-off value for CD45 was -94.33. The K-values for CD45 in non-severe case were above the cut-off values, indicating a 100% prediction success rate for severe and non-severe cases following SARS-CoV-2 infection. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly for the elderly. CD45 deficiency dysfunction the naïve and memory T lymphocytes which may affects the long-term effectiveness of COVID-19 vaccines. K-values of CD45 might be useful in distinguishing between severe and non-severe cases in the early infection. May be CD45 could increase the diagnostic sensitivity.

Keywords: COVID-19; clinical characteristics; coronavirus disease 2019; immunopathology; pneumonia; severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST: These authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Albumin expression in COVID-19 patients.
Figure 2
Figure 2
Expression of CRP and hs-CRP in COVID-19 patients.
Figure 3
Figure 3
CD3, CD8, and CD45 counts in COVID-19 patients.
Figure 4
Figure 4
K-values for CD3, CD8, and CD45.
Figure 5
Figure 5
K-value distributions of CD3 and CD45.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, et al., and China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382:727–33. 10.1056/NEJMoa2001017 - DOI - PMC - PubMed
    1. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020; 109:102433. 10.1016/j.jaut.2020.102433 - DOI - PMC - PubMed
    1. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395:809–15. 10.1016/S0140-6736(20)30360-3 - DOI - PMC - PubMed
    1. Pan L, Wang L, Huang X. How to face the novel coronavirus infection during the 2019-2020 epidemic: the experience of sichuan provincial people’s hospital. Intensive Care Med. 2020; 46:573–75. 10.1007/s00134-020-05964-0 - DOI - PMC - PubMed
    1. Khot WY, Nadkar MY. The 2019 novel coronavirus outbreak – a global threat. J Assoc Physicians India. 2020; 68:67–71. - PubMed

Publication types

MeSH terms