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Review
. 2021 Mar 1;273(3):483-493.
doi: 10.1097/SLA.0000000000004071.

Transplant Oncology in Primary and Metastatic Liver Tumors: Principles, Evidence, and Opportunities

Gonzalo Sapisochin  1 , Taizo Hibi  2 , Christian Toso  3 , Kwan Man  4 , Marina Berenguer  5 , Julie Heimbach  6 , Tim F Greten  7 , Trevor J Pugh  8   9   10 , Laura A Dawson  11 , Vincenzo Mazzaferro  12
Affiliations
Review

Transplant Oncology in Primary and Metastatic Liver Tumors: Principles, Evidence, and Opportunities

Gonzalo Sapisochin et al. Ann Surg. .

Abstract

Transplant oncology defines any application of transplant medicine and surgery aimed at improving cancer patients' survival and/or quality of life. In practice, liver transplantation for selected hepato-biliary cancers is the only solid organ transplant with demonstrated efficacy in curing cancer. Four are the proposed future contributions of transplant oncology in hepato-biliary cancer (4-e). (1) evolutionary approach to cancer care that includes liver transplantation; (2) elucidation of self and non-self recognition systems, by linking tumor and transplant immunology; (3) exploration of innovative endpoints both in clinical and experimental settings taking advantage from the access to the entire liver explant; (4) extension of surgical limitation in the multidisciplinary approach to hepato-biliary oncology. The aim of this review is to define the principles of transplant oncology that may be applied to hepato-biliary cancer treatment and research, attempting to balance current evidences with future opportunities.

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Conflict of interest statement

The authors declare no conflict of interests.

References

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