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. 2020 Nov;33(11):1-6.
doi: 10.1097/01.ASW.0000717228.02752.4e.

Efficacy of Surgical Excision and Brachytherapy in the Treatment of Keloids: A Retrospective Cohort Study

Mathieu Daurade  1 , Pierre Breton, Nathalie Rouard, Fabrice Lorchel, Badr Ibrahim, Nicolas Sigaux
Affiliations

Efficacy of Surgical Excision and Brachytherapy in the Treatment of Keloids: A Retrospective Cohort Study

Mathieu Daurade et al. Adv Skin Wound Care. 2020 Nov.

Abstract

Objective: To demonstrate the efficacy of a protocol combining surgical excision and high-dose-rate brachytherapy for treatment of keloids.

Methods: The authors performed a unicentric retrospective cohort study between 2013 and 2018. The minimum follow-up was 12 months. All patients treated for keloids at the authors' institution were included. Extralesional excision was performed with placement of a brachytherapy sheath under the skin. The total dose of irradiation was 18 Gy. The postoperative results were evaluated for aesthetic and functional outcomes with a validated scale, as well as the presence or absence of recurrence.

Results: Fifteen patients were lost to follow-up. Thirty-eight patients with 67 keloids were included. The control rate was 94%. The aesthetic and functional outcomes were considered good in 62% of cases. The main limitation of the study was the small patient population.

Conclusions: Extralesional excision combined with postoperative high-dose-rate brachytherapy seems to be one of the most effective invasive protocols to treat and prevent keloids.

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References

    1. Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg 2017;43Suppl 1:S3–18.
    1. Glass DA. Current understanding of the genetic causes of keloid formation. J Investig Dermatol Symp Proc 2017;18(2):S50–3.
    1. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci 2017;18(3).
    1. Bijlard E, Kouwenberg CAE, Timman R, Hovius SER, Busschbach JJV, Mureau MAM. Burden of keloid disease: a cross-sectional health-related quality of life assessment. Acta Derm Venereol 2017;97(2):225–9.
    1. Jaloux C, Bertrand B, Degardin N, Casanova D, Kerfant N, Philandrianos C. Keloid scars (part II): treatment and prevention [in French]. Ann Chir Plast Esthet 2017;62(1):87–96.

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