Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2021 Jan:39:154-157.
doi: 10.1016/j.ajem.2020.09.075. Epub 2020 Oct 1.

Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19

Sergey N Avdeev  1 , Andrey I Yaroshetskiy  2 , Natalia A Tsareva  2 , Zamira M Merzhoeva  2 , Natalia V Trushenko  2 , Galina V Nekludova  2 , Svetlana Yu Chikina  2
Affiliations
Multicenter Study

Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19

Sergey N Avdeev et al. Am J Emerg Med. 2021 Jan.

Abstract

Aim: Noninvasive ventilation (NIV) is known to reduce intubation in patients with acute hypoxemic respiratory failure (AHRF). We aimed to assess the outcomes of NIV application in COVID-19 patients with AHRF.

Materials & methods: In this retrospective cohort study, patients with confirmed diagnosis of COVID-19 and AHRF receiving NIV in general wards were recruited from two university-affiliated hospitals. Demographic, clinical, and laboratory data were recorded at admission. The failure of NIV was defined as intubation or death during the hospital stay.

Results: Between April 8 and June 10, 2020, 61 patients were enrolled into the final cohort. NIV was successful in 44 out of 61 patients (72.1%), 17 patients who failed NIV therapy were intubated, and among them 15 died. Overall mortality rate was 24.6%. Patients who failed NIV were older, and had higher respiratory rate, PaCO2, D-dimer levels before NIV and higher minute ventilation and ventilatory ratio on the 1-st day of NIV. No healthcare workers were infected with SARS-CoV-2 during the study period.

Conclusions: NIV is feasible in patients with COVID-19 and AHRF outside the intensive care unit, and it can be considered as a valuable option for the management of AHRF in these patients.

Keywords: Acute respiratory failure; COVID-19; Noninvasive ventilation.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors have no competing interests to declare.

Figures

Fig. 1
Fig. 1
Study flow chart.
See this image and copyright information in PMC

References

    1. Guan W., Ni Z., Hu Y., et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708–1720. doi: 10.1056/NEJMoa2002032. - DOI - PMC - PubMed
    1. Alhazzani W., Moller M.H., Arabi Y.M., et al. Surviving Sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19) Intensive Care Med. 2020;46:854–887. doi: 10.1007/s00134-020-06022-5. - DOI - PMC - PubMed
    1. Richardson S., Hirsch J.S., Narasimhan M., et al. Northwell COVID-19 research consortium. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020;323:2052–2059. doi: 10.1001/jama.2020.6775. - DOI - PMC - PubMed
    1. McGuinness G., Zhan C., Rosenberg N., Azour L., Wickstrom M., Mason D.M., et al. High incidence of barotrauma in patients with COVID-19 infection on invasive mechanical ventilation. Radiology. 2020 doi: 10.1148/radiol.2020202352. in press. - DOI - PMC - PubMed
    1. Chou R., Dana T., Buckley D.I., Selph S., Fu R., Totten A.M. Epidemiology of and risk factors for coronavirus infection in health care workers: a living rapid review. Ann Intern Med. 2020;173:120–136. doi: 10.7326/M20-1632. - DOI - PMC - PubMed

Publication types

LinkOut - more resources