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Review
. 2021 Feb;78(4):1369-1392.
doi: 10.1007/s00018-020-03667-9. Epub 2020 Oct 16.

Selective autophagy as a therapeutic target for neurological diseases

Weilin Xu #  1 , Umut Ocak #  2   3 , Liansheng Gao #  1 , Sheng Tu  4 , Cameron J Lenahan  5 , Jianmin Zhang  6   7   8 , Anwen Shao  9
Affiliations
Review

Selective autophagy as a therapeutic target for neurological diseases

Weilin Xu et al. Cell Mol Life Sci. 2021 Feb.

Abstract

The neurological diseases primarily include acute injuries, chronic neurodegeneration, and others (e.g., infectious diseases of the central nervous system). Autophagy is a housekeeping process responsible for the bulk degradation of misfolded protein aggregates and damaged organelles through the lysosomal machinery. Recent studies have suggested that autophagy, particularly selective autophagy, such as mitophagy, pexophagy, ER-phagy, ribophagy, lipophagy, etc., is closely implicated in neurological diseases. These forms of selective autophagy are controlled by a group of important proteins, including PTEN-induced kinase 1 (PINK1), Parkin, p62, optineurin (OPTN), neighbor of BRCA1 gene 1 (NBR1), and nuclear fragile X mental retardation-interacting protein 1 (NUFIP1). This review highlights the characteristics and underlying mechanisms of different types of selective autophagy, and their implications in various forms of neurological diseases.

Keywords: Alzheimer’s disease; Autophagy receptor; Macroautophagy; Neuroprotection; Parkinson’s disease; Stroke.

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Conflict of interest statement

The authors state that there was no conflict of interest in the preparation of this review.

Figures

Fig. 1
Fig. 1
Three types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy
Fig. 2
Fig. 2
The autophagy process of five common types of selective autophagy: a the process and regulatory mechanism of mitophagy; b the regulatory mechanism of pexophagy, ER-phagy, ribophagy, and lipophagy
See this image and copyright information in PMC

References

    1. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992;267(9):1244–1252. - PubMed
    1. Corrigan JD, Selassie AW, Orman JA. The epidemiology of traumatic brain injury. J Head Trauma Rehabil. 2010;25(2):72–80. - PubMed
    1. Mayeux R. Epidemiology of neurodegeneration. Annu Rev Neurosci. 2003;26:81–104. - PubMed
    1. Bramlett HM, Dietrich WD. Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J Cereb Blood Flow Metab. 2004;24(2):133–150. - PubMed
    1. Bossy-Wetzel E, Schwarzenbacher R, Lipton SA. Molecular pathways to neurodegeneration. Nat Med. 2004;10(Suppl):S2–S9. - PubMed

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