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. 2020 Dec;198(6):957-964.
doi: 10.1007/s00408-020-00396-5. Epub 2020 Oct 16.

Influence of Cystic Fibrosis-Related Diabetes on Mental Health in Adults: A Single-Center Study

Michelle Hjelm  1   2 , Dmitry Tumin  3 , Christopher J Nemastil  4 , Ann E Salvator  5 , Don Hayes Jr  6   7
Affiliations

Influence of Cystic Fibrosis-Related Diabetes on Mental Health in Adults: A Single-Center Study

Michelle Hjelm et al. Lung. 2020 Dec.

Erratum in

Abstract

Purpose: People with cystic fibrosis (CF) are predisposed to chronic conditions, such as CF-related diabetes (CFRD). Recent attention has been focused on the addition of screening for anxiety and depression in the CF population. Independently, CFRD and mental health conditions are associated with worse clinical outcomes; however, research assessing the impact of both conditions together is limited. We aimed to characterize the association between CFRD and selected diagnoses of anxiety or depressive disorders on clinical outcomes in adults with CF.

Methods: A single-center, retrospective, cross-sectional study in adult patients with CF was performed. Group comparisons included selected diagnoses of depression, anxiety, and CFRD using two-sample t-tests or rank-sum tests for continuous variables, and Chi-square or Fisher's exact tests for categorical variables.

Results: A total of 209 adults were enrolled (mean age of 31.4 ± 11.4 years). Those with a selected diagnoses of depression had a significantly higher proportion of CFRD than those without depression (48% vs. 28%, respectively, p = 0.005), and CFRD was associated with increased odds of depression [OR (CI) = 2.33 (1.28, 4.26), p = 0.006]. We did not see a higher proportion of adults with CFRD and selected diagnoses of anxiety than those without anxiety (41% vs. 31% respectively, p = 0.12), nor an increased odds of anxiety in those with CFRD [OR (CI) = 1.58 (0.88, 2.84), p = 0.12].

Conclusion: We show a significant association between CFRD and selected diagnoses of depression in a cohort of adult patients.

Keywords: Anxiety; Cystic fibrosis; Cystic fibrosis-related diabetes; depression.

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References

    1. Simmonds NJ (2013) Ageing in cystic fibrosis and long-term survival. Paediatr Respir Rev 14(Suppl 1):6–9. https://doi.org/10.1016/j.prrv.2013.01.007 - DOI - PubMed
    1. Parkins MD, Parkins VM, Rendall JC, Elborn S (2011) Changing epidemiology and clinical issues arising in an ageing cystic fibrosis population. Ther Adv Respir Dis 5(2):105–119. https://doi.org/10.1177/1753465810386051 - DOI - PubMed
    1. Ronan NJ, Elborn JS, Plant BJ (2017) Current and emerging comorbidities in cystic fibrosis. Presse Med (Paris France: 1983). https://doi.org/10.1016/j.lpm.2017.05.011 - DOI
    1. About Chronic Diseases. (2018) Centers for Disease Control and Prevention. https://www.cdc.gov/chronicdisease/about/index.htm . Accessed October 24 2018
    1. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B (2007) Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet (London, England) 370(9590):851–858. https://doi.org/10.1016/s0140-6736(07)61415-9 - DOI