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. 2021 Apr;15(2):1025-1032.
doi: 10.1007/s11682-020-00309-3.

Association of brain white matter lesions with arterial stiffness assessed by cardio-ankle vascular index. The Beijing Vascular Disease Evaluation STudy (BEST)

Huan Liu  1 , Jinbo Liu  1 , Hongwei Zhao  1 , Hongyu Wang  2 ; BEST research group
Affiliations

Association of brain white matter lesions with arterial stiffness assessed by cardio-ankle vascular index. The Beijing Vascular Disease Evaluation STudy (BEST)

Huan Liu et al. Brain Imaging Behav. 2021 Apr.

Abstract

Background-The association of brain white matter lesions with arterial stiffness, as assessed by the cardio-ankle vascular index, is not well characterized in the population.

Objective: The aim of this study was to quantify the cross-sectional association of brain white matter lesions with arterial stiffness assessed by the cardio-ankle vascular index among 1176 adults.

Methods: We used logistic regression to evaluate the associations of the cardio-ankle vascular index with brain white matter lesions, detected by computed tomography or magnetic resonance imaging, versus normal brain white matter.

Results: After adjustment for age, sex, systolic blood pressure, blood lipid level, C reactive protein level, homocysteine level, uric acid level, urea nitrogen level, creatinine level, hypertension, diabetes, coronary artery disease, peripheral artery disease, and stroke, the multivariable analysis showed that age, sex, systolic blood pressure, stroke and the cardio-ankle vascular index were independently associated with the presence of brain white matter lesions. Age range (odds ratio: from 2.48 to 33.64, all p < 0.05) showed the strongest association, followed by stroke (odds ratio: 7.16, 95% confidence interval: 4.59 to 11.16), male sex (odds ratio: 1.80, 95% confidence interval: 1.18 to 2.75), cardio-ankle vascular index (odds ratio: 1.26, 95% confidence interval: 1.06 to 1.50) and systolic blood pressure (odds ratio: 1.01, 95% confidence interval: 1.00 to 1.02).

Conclusion: Higher arterial stiffness assessed by the cardio-ankle vascular index was associated with the presence of brain white matter lesions. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness predicts brain white matter lesions.

Keywords: Arterial stiffness; Brain white matter lesions; Cardio-ankle vascular index (CAVI).

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References

    1. Au, R., Massaro, J. M., Wolf, P. A., Young, M. E., Beiser, A., Seshadri, S., D’Agostino, R. B., & DeCarli, C. (2006). Association of white matter hyperintensity volume with decreased cognitive functioning: The Framingham Heart Study. Archives of Neurology, 63(2), 246–250. - DOI
    1. Cooper, L. L., Woodard, T., Sigurdsson, S., van Buchem, M. A., Torjesen, A. A., Inker, L. A., Aspelund, T., Eiriksdottir, G., Harris, T. B., Gudnason, V., Launer, L. J., & Mitchell, G. F. (2016). Cerebrovascular damage mediates relations between aortic stiffness and memory. Hypertension., 67(1), 176–182. - DOI
    1. Gómez-Marcos, M. Á., Recio-Rodríguez, J. I., Patino-Alonso, M. C., Agudo-Conde, C., Gómez-Sánchez, L., Gomez-Sanchez, M., et al. (2015). Cardio-ankle vascular index is associated with cardiovascular target organ damage and vascular structure and function in patients with diabetes or metabolic syndrome, LOD-DIABETES study: a case series report. Cardiovascular Diabetology, 14, 7. - DOI
    1. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, , Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S, American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. American Heart Association Stroke Council CoE, prevention CoCNCoCR, intervention council on cardiovascular S, anesthesia. Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011; 42:2672–2713. - DOI
    1. Habes, M., Erus, G., Toledo, J. B., Zhang, T., Bryan, N., Launer, L. J., Rosseel, Y., Janowitz, D., Doshi, J., van der Auwera, S., von Sarnowski, B., Hegenscheid, K., Hosten, N., Homuth, G., Völzke, H., Schminke, U., Hoffmann, W., Grabe, H. J., & Davatzikos, C. (2016). White matter hyperintensities and imaging patterns of brain ageing in the general population. Brain., 139(Pt 4), 1164–1179. - DOI

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