Perspectives on Model-Informed Precision Dosing in the Digital Health Era: Challenges, Opportunities, and Recommendations

Franziska Kluwe^{1

2}, Robin Michelet¹, Anna Mueller-Schoell^{1

2}, Corinna Maier^{2

3}, Lena Klopp-Schulze^{1

2}, Madelé van Dyk⁴, Gerd Mikus^{1

5}, Wilhelm Huisinga³, Charlotte Kloft¹

Affiliations

¹ Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
² Graduate Research Training Program PharMetrX, Freie Universität Berlin and Universitaet Potsdam, Berlin, Germany.
³ Institute of Mathematics, Universität Potsdam, Potsdam, Germany.
⁴ Flinders Centre for Innovation in Cancer, College of Medicine & Public Health, Flinders University, Adelaide, Australia.
⁵ Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

Franziska Kluwe et al. Clin Pharmacol Ther. 2021 Jan.

. 2021 Jan;109(1):29-36.

doi: 10.1002/cpt.2049. Epub 2020 Oct 17.

Franziska Kluwe^{1

2}, Robin Michelet¹, Anna Mueller-Schoell^{1

2}, Corinna Maier^{2

3}, Lena Klopp-Schulze^{1

2}, Madelé van Dyk⁴, Gerd Mikus^{1

5}, Wilhelm Huisinga³, Charlotte Kloft¹

¹ Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
² Graduate Research Training Program PharMetrX, Freie Universität Berlin and Universitaet Potsdam, Berlin, Germany.
³ Institute of Mathematics, Universität Potsdam, Potsdam, Germany.
⁴ Flinders Centre for Innovation in Cancer, College of Medicine & Public Health, Flinders University, Adelaide, Australia.
⁵ Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

No abstract available

References

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1. Klopp-Schulze, L. et al. Integrated data analysis of six clinical studies points toward model-informed precision dosing of tamoxifen. Front. Pharmacol. 11, 1-19 (2020).
1. Kumar, A.A. et al. An evaluation of the user-friendliness of Bayesian forecasting programs in a clinical setting. Br. J. Clin. Pharmacol. 85, 2436-2441 (2019).