Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system
- PMID: 33071256
- DOI: 10.2220/biomedres.41.199
Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system
Abstract
The microbiota-gut-brain axis transmits bidirectional communication between the gut and the central nervous system and links the emotional and cognitive centers of the brain with peripheral gut functions. This communication occurs along the axis via local, paracrine, and endocrine mechanisms involving a variety of gut-derived peptide/amine produced by enteroendocrine cells. Neural networks, such as the enteric nervous system, and the central nervous system, including the autonomic nervous system, also transmit information through the microbiota-gut-brain axis. Recent advances in research have described the importance of the gut microbiota in influencing normal physiology and contributing to disease. We are only beginning to understand this bidirectional communication system. In this review, we summarize the available data supporting the existence of these interactions, highlighting data related to the contribution of enteroendocrine cells and the enteric nervous system as an interface between the gut microbiota and brain.
Similar articles
-
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics.J Microbiol. 2018 Mar;56(3):172-182. doi: 10.1007/s12275-018-8032-4. Epub 2018 Feb 28. J Microbiol. 2018. PMID: 29492874 Review.
-
Gut Microbiota-brain Axis.Chin Med J (Engl). 2016 Oct 5;129(19):2373-80. doi: 10.4103/0366-6999.190667. Chin Med J (Engl). 2016. PMID: 27647198 Free PMC article. Review.
-
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. Ann Gastroenterol. 2015. PMID: 25830558 Free PMC article.
-
The intestinal microbiome, probiotics and prebiotics in neurogastroenterology.Gut Microbes. 2013 Jan-Feb;4(1):17-27. doi: 10.4161/gmic.22973. Epub 2012 Nov 30. Gut Microbes. 2013. PMID: 23202796 Free PMC article. Review.
-
Gut feelings: the microbiota-gut-brain axis on steroids.Am J Physiol Gastrointest Liver Physiol. 2022 Jan 1;322(1):G1-G20. doi: 10.1152/ajpgi.00294.2021. Epub 2021 Nov 3. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 34730020 Free PMC article. Review.
Cited by
-
Spice-Derived Bioactive Compounds Confer Colorectal Cancer Prevention via Modulation of Gut Microbiota.Cancers (Basel). 2022 Nov 19;14(22):5682. doi: 10.3390/cancers14225682. Cancers (Basel). 2022. PMID: 36428774 Free PMC article. Review.
-
A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine.Braz J Med Biol Res. 2022 Aug 22;55:e11910. doi: 10.1590/1414-431X2022e11910. eCollection 2022. Braz J Med Biol Res. 2022. PMID: 36000611 Free PMC article. Review.
-
D-Amino Acids as a Biomarker in Schizophrenia.Diseases. 2022 Jan 31;10(1):9. doi: 10.3390/diseases10010009. Diseases. 2022. PMID: 35225861 Free PMC article. Review.
-
Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions.Int J Mol Sci. 2023 Apr 29;24(9):8061. doi: 10.3390/ijms24098061. Int J Mol Sci. 2023. PMID: 37175764 Free PMC article. Review.
-
The interplay between microbiota and brain-gut axis in epilepsy treatment.Front Pharmacol. 2024 Jan 26;15:1276551. doi: 10.3389/fphar.2024.1276551. eCollection 2024. Front Pharmacol. 2024. PMID: 38344171 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources