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Review
. 2020 Sep 15:11:1914.
doi: 10.3389/fimmu.2020.01914. eCollection 2020.

Immune Functions of Erythrocytes in Osteichthyes

Michał Stosik  1 , Beata Tokarz-Deptuła  2 , Jakub Deptuła  3 , Wiesław Deptuła  4
Affiliations
Review

Immune Functions of Erythrocytes in Osteichthyes

Michał Stosik et al. Front Immunol. .

Abstract

Red blood cells (RBCs)-erythrocytes-of Osteichthyes are primarily known for their involvement in the process of gas exchange and respiration. Currently, physiological properties of RCBs in fish should also include their ability to participate in defense processes as part of the innate and adaptive immune mechanisms. In response to viruses, bacteria, and fungi or recombinant nanoparticles, they can modulate expression of genes responsible for immune reactions, influence activity of leukocytes, and produce cytokines, antimicrobial peptides, and paracrine intercellular signaling molecules. Via the complement system (CR1 receptor) and owing to their phagocytic properties (erythrophagocytosis), RBCs of Osteichthyes can eliminate pathogens. In addition, they are probably involved in the immune response as antigen-presenting cells via major histocompatibility complex class II antigens.

Keywords: bacteria; erythrocytes; fish; fungi; immunity; viruses.

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References

    1. Witeska M. Erythrocytes in teleost fishes: a review. Zool Ecol. (2013) 23:275–81. 10.1080/21658005.2013.846963 - DOI
    1. Morera D, Roher N, Ribas L, Balasch JC, Doñate C, Callol A, et al. . RNA-Seq reveals an integrated immune response in nucleated erythrocytes. PLoS ONE. (2011) 6:e26998. 10.1371/journal.pone.0026998 - DOI - PMC - PubMed
    1. Pereiro P, Romero A, Díaz-Rosales P, Estepa A, Figueras A, Novoa B. Nucleated teleost erythrocytes play an Nk-Lysin- and autophagy-dependent role in antiviral immunity. Front Immunol. (2017) 8:1458. 10.3389/fimmu.2017.01458 - DOI - PMC - PubMed
    1. Chico V, Salvador-Mira ME, Nombela I, Puente-Marin S, Ciordia S, Mena MC, et al. . IFIT5 participates in the antiviral mechanisms of rainbow trout red blood cells. Front Immunol. (2019) 10:613. 10.3389/fimmu.2019.00613 - DOI - PMC - PubMed
    1. Chico V, Puente-Marin S, Nombela I, Ciordia S, Mena MC, Carracedo B, et al. . Shape-shifted red blood cells: a novel red blood cell stage? Cells. (2018) 7:31. 10.3390/cells7040031 - DOI - PMC - PubMed

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